Literature DB >> 23637409

Host IQGAP1 and Ebola virus VP40 interactions facilitate virus-like particle egress.

Jianhong Lu1, Yonggang Qu, Yuliang Liu, Rakesh Jambusaria, Ziying Han, Gordon Ruthel, Bruce D Freedman, Ronald N Harty.   

Abstract

We have identified host IQGAP1 as an interacting partner for Ebola virus (EBOV) VP40, and its expression is required for EBOV VP40 virus-like particle (VLP) budding. IQGAP1 is involved in actin cytoskeletal remodeling during cell migration and formation of filopodia. The physical interaction and the functional requirement for IQGAP1 in EBOV VP40 VLP egress link virus budding to the cytoskeletal remodeling machinery. Consequently, this interaction represents a novel target for development of therapeutics to block budding and transmission of filoviruses.

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Year:  2013        PMID： 23637409      PMCID： PMC3700276          DOI： 10.1128/JVI.00470-13

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  25 in total

1.  A PPxY motif within the VP40 protein of Ebola virus interacts physically and functionally with a ubiquitin ligase: implications for filovirus budding.

Authors:  R N Harty; M E Brown; G Wang; J Huibregtse; F P Hayes
Journal:  Proc Natl Acad Sci U S A       Date:  2000-12-05       Impact factor: 11.205

2.  Overlapping motifs (PTAP and PPEY) within the Ebola virus VP40 protein function independently as late budding domains: involvement of host proteins TSG101 and VPS-4.

Authors:  Jillian M Licata; Martha Simpson-Holley; Nathan T Wright; Ziying Han; Jason Paragas; Ronald N Harty
Journal:  J Virol       Date:  2003-02       Impact factor: 5.103

Review 3.  IQGAP1: a key regulator of adhesion and migration.

Authors:  Jun Noritake; Takashi Watanabe; Kazumasa Sato; Shujie Wang; Kozo Kaibuchi
Journal:  J Cell Sci       Date:  2005-05-15       Impact factor: 5.285

4.  Human ESCRT and ALIX proteins interact with proteins of the midbody and function in cytokinesis.

Authors:  Eiji Morita; Virginie Sandrin; Hyo-Young Chung; Scott G Morham; Steven P Gygi; Christopher K Rodesch; Wesley I Sundquist
Journal:  EMBO J       Date:  2007-09-13       Impact factor: 11.598

Review 5.  IQGAP1 in microbial pathogenesis: Targeting the actin cytoskeleton.

Authors:  Hugh Kim; Colin D White; David B Sacks
Journal:  FEBS Lett       Date:  2011-02-02       Impact factor: 4.124

Review 6.  Filovirus budding.

Authors:  Luke D Jasenosky; Yoshihiro Kawaoka
Journal:  Virus Res       Date:  2004-12       Impact factor: 3.303

Review 7.  Emerging and reemerging of filoviruses.

Authors:  H Feldmann; W Slenczka; H D Klenk
Journal:  Arch Virol Suppl       Date:  1996

Review 8.  Visualization of molecular interactions by fluorescence complementation.

Authors:  Tom K Kerppola
Journal:  Nat Rev Mol Cell Biol       Date:  2006-06       Impact factor: 94.444

Review 9.  An emerging role for IQGAP1 in regulating protein traffic.

Authors:  Mahasin Osman
Journal:  ScientificWorldJournal       Date:  2010-05-18

10.  Role for amino acids 212KLR214 of Ebola virus VP40 in assembly and budding.

Authors:  Sarah E McCarthy; Reed F Johnson; Yong-An Zhang; J Oriol Sunyer; Ronald N Harty
Journal:  J Virol       Date:  2007-08-15       Impact factor: 5.103
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  35 in total

1.  Predictive and comparative analysis of Ebolavirus proteins.

Authors:  Qian Cong; Jimin Pei; Nick V Grishin
Journal:  Cell Cycle       Date:  2015-07-09       Impact factor: 4.534

Review 2.  The biology of IQGAP proteins: beyond the cytoskeleton.

Authors:  Andrew C Hedman; Jessica M Smith; David B Sacks
Journal:  EMBO Rep       Date:  2015-02-26       Impact factor: 8.807

Review 3.  Seeking Closure: How Do Herpesviruses Recruit the Cellular ESCRT Apparatus?

Authors:  Jenna Barnes; Duncan W Wilson
Journal:  J Virol       Date:  2019-06-14       Impact factor: 5.103

4.  IQGAP2 is a novel interferon-alpha antiviral effector gene acting non-conventionally through the NF-κB pathway.

Authors:  Cynthia Brisac; Shadi Salloum; Victor Yang; Esperance A K Schaefer; Jacinta A Holmes; Stephane Chevaliez; Jian Hong; Charlie Carlton-Smith; Nadia Alatrakchi; Annie Kruger; Wenyu Lin; Raymond T Chung
Journal:  J Hepatol       Date:  2016-07-09       Impact factor: 25.083

5.  Small-molecule probes targeting the viral PPxY-host Nedd4 interface block egress of a broad range of RNA viruses.

Authors:  Ziying Han; Jianhong Lu; Yuliang Liu; Benjamin Davis; Michael S Lee; Mark A Olson; Gordon Ruthel; Bruce D Freedman; Matthias J Schnell; Jay E Wrobel; Allen B Reitz; Ronald N Harty
Journal:  J Virol       Date:  2014-04-16       Impact factor: 5.103

6.  ALIX Rescues Budding of a Double PTAP/PPEY L-Domain Deletion Mutant of Ebola VP40: A Role for ALIX in Ebola Virus Egress.

Authors:  Ziying Han; Jonathan J Madara; Yuliang Liu; Wenbo Liu; Gordon Ruthel; Bruce D Freedman; Ronald N Harty
Journal:  J Infect Dis       Date:  2015-03-18       Impact factor: 5.226

7.  ITCH E3 Ubiquitin Ligase Interacts with Ebola Virus VP40 To Regulate Budding.

Authors:  Ziying Han; Cari A Sagum; Mark T Bedford; Sachdev S Sidhu; Marius Sudol; Ronald N Harty
Journal:  J Virol       Date:  2016-09-29       Impact factor: 5.103

8.  The multifunctional Ebola virus VP40 matrix protein is a promising therapeutic target.

Authors:  Jonathan J Madara; Ziying Han; Gordon Ruthel; Bruce D Freedman; Ronald N Harty
Journal:  Future Virol       Date:  2015-05       Impact factor: 1.831

9.  Ebola virus proteins NP, VP35, and VP24 are essential and sufficient to mediate nucleocapsid transport.

Authors:  Yuki Takamatsu; Larissa Kolesnikova; Stephan Becker
Journal:  Proc Natl Acad Sci U S A       Date:  2018-01-16       Impact factor: 11.205

Review 10.  Virus budding and the ESCRT pathway.

Authors:  Jörg Votteler; Wesley I Sundquist
Journal:  Cell Host Microbe       Date:  2013-09-11       Impact factor: 21.023
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