OBJECTIVE: To determine whether serum paraoxonase (PON) and arylesterase (ARE) activity might predict sepsis mortality. METHODS: Patients with sepsis and healthy control subjects were enrolled in this retrospective study. Serum PON and ARE activity levels were measured. Patients were stratified according to 30-day mortality rates. RESULTS: Serum PON and ARE activity levels were significantly lower in patients with sepsis (n = 61) than in healthy controls (n = 32), and were significantly lower in nonsurviving patients (n = 22) than in surviving patients (n = 39). Low PON and ARE activity levels were significantly correlated with poor overall survival in patients with sepsis. CONCLUSIONS: Decreased serum PON and ARE activity is related to poor prognosis in patients with sepsis. Measuring the activity of PON and ARE may represent a new method for evaluating the prognosis of sepsis. In addition, both PON and ARE are potential molecular treatment targets for sepsis.
OBJECTIVE: To determine whether serum paraoxonase (PON) and arylesterase (ARE) activity might predict sepsis mortality. METHODS:Patients with sepsis and healthy control subjects were enrolled in this retrospective study. Serum PON and ARE activity levels were measured. Patients were stratified according to 30-day mortality rates. RESULTS: Serum PON and ARE activity levels were significantly lower in patients with sepsis (n = 61) than in healthy controls (n = 32), and were significantly lower in nonsurviving patients (n = 22) than in surviving patients (n = 39). Low PON and ARE activity levels were significantly correlated with poor overall survival in patients with sepsis. CONCLUSIONS: Decreased serum PON and ARE activity is related to poor prognosis in patients with sepsis. Measuring the activity of PON and ARE may represent a new method for evaluating the prognosis of sepsis. In addition, both PON and ARE are potential molecular treatment targets for sepsis.
Authors: Donatella Scavone; Micaela Sgorbini; Alexandre S Borges; José P Oliveira-Filho; Valentina Vitale; Saverio Paltrinieri Journal: BMC Vet Res Date: 2020-11-04 Impact factor: 2.741