BACKGROUND: Effects of chronic cadmium exposure on liver disease and liver-related mortality are unknown. We evaluated the association of creatinine-corrected urinary cadmium levels with hepatic necroinflammation, non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), liver-related mortality, and liver cancer mortality in the US general population. METHODS: We analyzed the relationship of individuals in the top quartile for urinary cadmium measured in 12,732 adults who participated in the Third National Health and Nutrition Examination Survey in 1988-1994 (NHANES III), and hepatic necroinflammation, NAFLD, and NASH. Associations between cadmium, liver-related mortality, and liver cancer mortality were evaluated in the NHANES III mortality follow-up study. RESULTS: The cutoffs for highest quartile of urinary cadmium per gram of urinary creatinine were 0.65 and 0.83 μg/g for men and women, respectively (P < 0.001). After multivariate adjustment for other factors including smoking, the odds ratios [95 % confidence intervals (CI)] for hepatic necroinflammation, NAFLD, and NASH associated with being in the top quartile of cadmium levels by gender, were 2.21 (95 % CI, 1.64-3.00), 1.30 (95 % CI, 1.01-1.68) and 1.95 (95 % CI, 1.11-3.41) for men and 1.26 (95 % CI, 1.01-1.57), 1.11 (95 % CI, 0.88-1.41) and 1.34 (95 % CI, 0.72-2.50) for women, respectively. The hazard ratios for liver-related mortality and liver cancer mortality for both genders were 3.42 (95 % CI, 1.12-10.47) and 1.25 (95 % CI, 0.37-4.27). CONCLUSIONS: Environmental cadmium exposure was associated with hepatic necroinflammation, NAFLD, and NASH in men, and hepatic necroinflammation in women. Individuals in the top quartile of creatinine-corrected urinary cadmium had over a threefold increased risk of liver disease mortality but not in liver cancer related mortality.
BACKGROUND: Effects of chronic cadmium exposure on liver disease and liver-related mortality are unknown. We evaluated the association of creatinine-corrected urinary cadmium levels with hepatic necroinflammation, non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), liver-related mortality, and liver cancer mortality in the US general population. METHODS: We analyzed the relationship of individuals in the top quartile for urinary cadmium measured in 12,732 adults who participated in the Third National Health and Nutrition Examination Survey in 1988-1994 (NHANES III), and hepatic necroinflammation, NAFLD, and NASH. Associations between cadmium, liver-related mortality, and liver cancer mortality were evaluated in the NHANES III mortality follow-up study. RESULTS: The cutoffs for highest quartile of urinary cadmium per gram of urinary creatinine were 0.65 and 0.83 μg/g for men and women, respectively (P < 0.001). After multivariate adjustment for other factors including smoking, the odds ratios [95 % confidence intervals (CI)] for hepatic necroinflammation, NAFLD, and NASH associated with being in the top quartile of cadmium levels by gender, were 2.21 (95 % CI, 1.64-3.00), 1.30 (95 % CI, 1.01-1.68) and 1.95 (95 % CI, 1.11-3.41) for men and 1.26 (95 % CI, 1.01-1.57), 1.11 (95 % CI, 0.88-1.41) and 1.34 (95 % CI, 0.72-2.50) for women, respectively. The hazard ratios for liver-related mortality and liver cancer mortality for both genders were 3.42 (95 % CI, 1.12-10.47) and 1.25 (95 % CI, 0.37-4.27). CONCLUSIONS: Environmental cadmium exposure was associated with hepatic necroinflammation, NAFLD, and NASH in men, and hepatic necroinflammation in women. Individuals in the top quartile of creatinine-corrected urinary cadmium had over a threefold increased risk of liver disease mortality but not in liver cancer related mortality.
Authors: Maria Tellez-Plaza; Ana Navas-Acien; Ciprian M Crainiceanu; A Richey Sharrett; Eliseo Guallar Journal: Am J Epidemiol Date: 2010-08-06 Impact factor: 4.897
Authors: Pietro Manuel Ferraro; Stefano Costanzi; Alessandro Naticchia; Antonio Sturniolo; Giovanni Gambaro Journal: BMC Public Health Date: 2010-06-03 Impact factor: 3.295
Authors: Mariana Lazo; Ruben Hernaez; Susanne Bonekamp; Ihab R Kamel; Frederick L Brancati; Eliseo Guallar; Jeanne M Clark Journal: BMJ Date: 2011-11-18
Authors: Andy Menke; Paul Muntner; Ellen K Silbergeld; Elizabeth A Platz; Eliseo Guallar Journal: Environ Health Perspect Date: 2008-09-03 Impact factor: 9.031
Authors: Laura Cartularo; Freda Laulicht; Hong Sun; Thomas Kluz; Jonathan H Freedman; Max Costa Journal: Toxicol Appl Pharmacol Date: 2015-08-24 Impact factor: 4.219
Authors: Xin Hu; Joshua D Chandler; Jolyn Fernandes; Michael L Orr; Li Hao; Karan Uppal; David C Neujahr; Dean P Jones; Young-Mi Go Journal: Biochim Biophys Acta Gen Subj Date: 2018-04-12 Impact factor: 3.770
Authors: Young-Mi Go; Roy L Sutliff; Joshua D Chandler; Rahman Khalidur; Bum-Yong Kang; Frank A Anania; Michael Orr; Li Hao; Bruce A Fowler; Dean P Jones Journal: Toxicol Sci Date: 2015-07-16 Impact factor: 4.849
Authors: Emily J Werder; Juliane I Beier; Dale P Sandler; Keith C Falkner; Tyler Gripshover; Banrida Wahlang; Lawrence S Engel; Matthew C Cave Journal: Food Chem Toxicol Date: 2020-03-20 Impact factor: 6.023