Steven Greenberg1. 1. Respiratory & Immunology, Clinical Research, Merck Research Laboratories, Kenilworth, NJ 07033, USA. steven_greenberg@merck.com
Abstract
PURPOSE OF REVIEW: Asthma is a multifaceted disease that is associated with decreased lung function, multiple symptoms, varying levels of asthma control, and risk of acute exacerbations. The ability to predict the risk of developing acute exacerbations may improve the management of asthmatics and facilitate identification of these patients for interventional studies. RECENT FINDINGS: Factors that are associated with different manifestations of asthma differ. Biomarkers that are correlated with airways hyper-responsiveness do not necessarily correlate with risk of future exacerbations. Genetic factors that segregate with exacerbation risk are beginning to emerge. Outcome measures that demonstrate predictive validity have been developed and may facilitate patient management and provide novel clinically meaningful endpoints in clinical trials. SUMMARY: This review will emphasize underlying factors associated with asthma exacerbations and clinical prediction rules that correlate with the risk of developing severe exacerbations of asthma.
PURPOSE OF REVIEW: Asthma is a multifaceted disease that is associated with decreased lung function, multiple symptoms, varying levels of asthma control, and risk of acute exacerbations. The ability to predict the risk of developing acute exacerbations may improve the management of asthmatics and facilitate identification of these patients for interventional studies. RECENT FINDINGS: Factors that are associated with different manifestations of asthma differ. Biomarkers that are correlated with airways hyper-responsiveness do not necessarily correlate with risk of future exacerbations. Genetic factors that segregate with exacerbation risk are beginning to emerge. Outcome measures that demonstrate predictive validity have been developed and may facilitate patient management and provide novel clinically meaningful endpoints in clinical trials. SUMMARY: This review will emphasize underlying factors associated with asthma exacerbations and clinical prediction rules that correlate with the risk of developing severe exacerbations of asthma.
Authors: Michael J McGeachie; Ann C Wu; Sze Man Tse; George L Clemmer; Joanne Sordillo; Blanca E Himes; Jessica Lasky-Su; Robert P Chase; Fernando D Martinez; Peter Weeke; Christian M Shaffer; Hua Xu; Josh C Denny; Dan M Roden; Reynold A Panettieri; Benjamin A Raby; Scott T Weiss; Kelan G Tantisira Journal: J Allergy Clin Immunol Date: 2015-06-12 Impact factor: 10.793
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