Literature DB >> 23634258

Deciphering the New Role of the Greatwall/PP2A Pathway in Cell Cycle Control.

Thierry Lorca1, Anna Castro.   

Abstract

Mitotic division is induced by protein phosphorylation. For a long time the supported hypothesis was that mitotic entry and exit were the exclusive result of cyclin B-Cdk1 kinase activation and inactivation, whereas the phosphatase activity required to dephosphorylate mitotic substrates was thought to be constant during mitosis. Recent data demonstrate that phosphatase activity must also be tightly regulated to promote correct cell division. Here we describe the new pathway involved in phosphatase regulation and the questions that this discovery raises concerning the classic view of cell cycle regulation.

Entities:  

Keywords:  Greatwall; PP2A; mitosis

Year:  2012        PMID： 23634258      PMCID： PMC3636756          DOI： 10.1177/1947601912473478

Source DB:  PubMed          Journal:  Genes Cancer        ISSN： 1947-6019


  46 in total

1.  Genome-wide survey of protein kinases required for cell cycle progression.

Authors:  M Bettencourt-Dias; R Giet; R Sinka; A Mazumdar; W G Lock; F Balloux; P J Zafiropoulos; S Yamaguchi; S Winter; R W Carthew; M Cooper; D Jones; L Frenz; D M Glover
Journal:  Nature       Date:  2004-12-23       Impact factor: 49.962

2.  The tumor suppressor PP2A is functionally inactivated in blast crisis CML through the inhibitory activity of the BCR/ABL-regulated SET protein.

Authors:  Paolo Neviani; Ramasamy Santhanam; Rossana Trotta; Mario Notari; Bradley W Blaser; Shujun Liu; Hsiaoyin Mao; Ji Suk Chang; Annamaria Galietta; Ashwin Uttam; Denis C Roy; Mauro Valtieri; Rebecca Bruner-Klisovic; Michael A Caligiuri; Clara D Bloomfield; Guido Marcucci; Danilo Perrotti
Journal:  Cancer Cell       Date:  2005-11       Impact factor: 31.743

3.  Negative regulation of mitosis by wee1+, a gene encoding a protein kinase homolog.

Authors:  P Russell; P Nurse
Journal:  Cell       Date:  1987-05-22       Impact factor: 41.582

4.  Endosulfine, an endogenous peptidic ligand for the sulfonylurea receptor: purification and partial characterization from ovine brain.

Authors:  A Virsolvy-Vergine; H Leray; S Kuroki; B Lupo; M Dufour; D Bataille
Journal:  Proc Natl Acad Sci U S A       Date:  1992-07-15       Impact factor: 11.205

5.  Constant regulation of both the MPF amplification loop and the Greatwall-PP2A pathway is required for metaphase II arrest and correct entry into the first embryonic cell cycle.

Authors:  Thierry Lorca; Cyril Bernis; Suzanne Vigneron; Andrew Burgess; Estelle Brioudes; Jean-Claude Labbé; Anna Castro
Journal:  J Cell Sci       Date:  2010-07-01       Impact factor: 5.285

6.  Alpha-synuclein activation of protein phosphatase 2A reduces tyrosine hydroxylase phosphorylation in dopaminergic cells.

Authors:  Xiangmin Peng; Xiangmin M Peng; Roya Tehranian; Paula Dietrich; Leonidas Stefanis; Ruth G Perez
Journal:  J Cell Sci       Date:  2005-07-19       Impact factor: 5.285

7.  alpha-Endosulfine is a conserved protein required for oocyte meiotic maturation in Drosophila.

Authors:  Jessica R Von Stetina; Susanne Tranguch; Sudhansu K Dey; Laura A Lee; Byeong Cha; Daniela Drummond-Barbosa
Journal:  Development       Date:  2008-10-16       Impact factor: 6.868

8.  Conformation-specific binding of alpha-synuclein to novel protein partners detected by phage display and NMR spectroscopy.

Authors:  Wendy S Woods; John M Boettcher; Donghua H Zhou; Kathryn D Kloepper; Kevin L Hartman; Daniel T Ladror; Zhi Qi; Chad M Rienstra; Julia M George
Journal:  J Biol Chem       Date:  2007-09-24       Impact factor: 5.157

9.  PP1-mediated dephosphorylation of phosphoproteins at mitotic exit is controlled by inhibitor-1 and PP1 phosphorylation.

Authors:  Judy Qiju Wu; Jessie Yanxiang Guo; Wanli Tang; Chih-Sheng Yang; Christopher D Freel; Chen Chen; Angus C Nairn; Sally Kornbluth
Journal:  Nat Cell Biol       Date:  2009-04-26       Impact factor: 28.824

10.  Cdc2 H1 kinase is negatively regulated by a type 2A phosphatase in the Xenopus early embryonic cell cycle: evidence from the effects of okadaic acid.

Authors:  M A Félix; P Cohen; E Karsenti
Journal:  EMBO J       Date:  1990-03       Impact factor: 11.598
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  10 in total

1.  Greatwall-phosphorylated Endosulfine is both an inhibitor and a substrate of PP2A-B55 heterotrimers.

Authors:  Byron C Williams; Joshua J Filter; Kristina A Blake-Hodek; Brian E Wadzinski; Nicholas J Fuda; David Shalloway; Michael L Goldberg
Journal:  Elife       Date:  2014-03-11       Impact factor: 8.140

2.  Activation of p107 by fibroblast growth factor, which is essential for chondrocyte cell cycle exit, is mediated by the protein phosphatase 2A/B55α holoenzyme.

Authors:  Alison Kurimchak; Dale S Haines; Judit Garriga; Shufang Wu; Francesco De Luca; Michael J Sweredoski; Raymond J Deshaies; Sonja Hess; Xavier Graña
Journal:  Mol Cell Biol       Date:  2013-06-17       Impact factor: 4.272

3.  The phosphorylation of ARPP19 by Greatwall renders the auto-amplification of MPF independently of PKA in Xenopus oocytes.

Authors:  Aude Dupré; Eulalie Buffin; Chloé Roustan; Angus C Nairn; Catherine Jessus; Olivier Haccard
Journal:  J Cell Sci       Date:  2013-06-18       Impact factor: 5.285

4.  The potential role of As-sumo-1 in the embryonic diapause process and early embryo development of Artemia sinica.

Authors:  Bing Chu; Feng Yao; Cheng Cheng; Yang Wu; Yanli Mei; Xuejie Li; Yan Liu; Peisheng Wang; Lin Hou; Xiangyang Zou
Journal:  PLoS One       Date:  2014-01-03       Impact factor: 3.240

5.  PP2A inhibitors arrest G2/M transition through JNK/Sp1- dependent down-regulation of CDK1 and autophagy-dependent up-regulation of p21.

Authors:  Fei-Ran Gong; Meng-Yao Wu; Meng Shen; Qiaoming Zhi; Ze-Kuan Xu; Rong Wang; Wen-Jie Wang; Yang Zong; Zeng-Liang Li; Yadi Wu; Binhua P Zhou; Kai Chen; Min Tao; Wei Li
Journal:  Oncotarget       Date:  2015-07-30

6.  Reciprocal regulation of ARPP-16 by PKA and MAST3 kinases provides a cAMP-regulated switch in protein phosphatase 2A inhibition.

Authors:  Veronica Musante; Lu Li; Jean Kanyo; Tukiet T Lam; Christopher M Colangelo; Shuk Kei Cheng; A Harrison Brody; Paul Greengard; Nicolas Le Novère; Angus C Nairn
Journal:  Elife       Date:  2017-06-14       Impact factor: 8.140

Review 7.  PP2A-B55 Holoenzyme Regulation and Cancer.

Authors:  Perrine Goguet-Rubio; Priya Amin; Sushil Awal; Suzanne Vigneron; Sophie Charrasse; Francisca Mechali; Jean Claude Labbé; Thierry Lorca; Anna Castro
Journal:  Biomolecules       Date:  2020-11-22

8.  Partial inhibition of Cdk1 in G 2 phase overrides the SAC and decouples mitotic events.

Authors:  Rachael A McCloy; Samuel Rogers; C Elizabeth Caldon; Thierry Lorca; Anna Castro; Andrew Burgess
Journal:  Cell Cycle       Date:  2014-03-06       Impact factor: 4.534

Review 9.  PP2A: more than a reset switch to activate pRB proteins during the cell cycle and in response to signaling cues.

Authors:  Alison Kurimchak; Xavier Graña
Journal:  Cell Cycle       Date:  2015       Impact factor: 4.534

10.  Mastl is required for timely activation of APC/C in meiosis I and Cdk1 reactivation in meiosis II.

Authors:  Deepak Adhikari; M Kasim Diril; Kiran Busayavalasa; Sanjiv Risal; Shoma Nakagawa; Rebecca Lindkvist; Yan Shen; Vincenzo Coppola; Lino Tessarollo; Nobuaki R Kudo; Philipp Kaldis; Kui Liu
Journal:  J Cell Biol       Date:  2014-09-22       Impact factor: 10.539
  10 in total

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