Literature DB >> 23634116

N-(2,6-Dimeth-oxy-pyridin-3-yl)-9-methyl-9H-carbazole-3-sulfonamide.

Guangzhi Shan1, Zhuorong Li, Laixing Hu, Jiandong Jiang, Zongying Liu.   

Abstract

In the title compound, C20H19N3O4S, a novel tubulin ligand active against human cancer, the dihedral angle between the pyridine ring and the carbazole ring system is 42.87 (10)°. In the crystal, the mol-ecules are held together by N-H⋯O and C-H⋯O hydrogen bonds into layers, which are assembled into a three-dimensional network via π-π stacking inter-actions between inversion-related pyridine rings, with centroid-centroid distances of 3.5101 (12) Å.

Entities:  

Year:  2013        PMID: 23634116      PMCID: PMC3629629          DOI: 10.1107/S1600536813007460

Source DB:  PubMed          Journal:  Acta Crystallogr Sect E Struct Rep Online        ISSN: 1600-5368


  8 in total

Review 1.  Modulation of microtubule dynamics by drugs: a paradigm for the actions of cellular regulators.

Authors:  L Wilson; D Panda; M A Jordan
Journal:  Cell Struct Funct       Date:  1999-10       Impact factor: 2.212

2.  Mechanism of inhibition of cell proliferation by Vinca alkaloids.

Authors:  M A Jordan; D Thrower; L Wilson
Journal:  Cancer Res       Date:  1991-04-15       Impact factor: 12.701

Review 3.  Targeted anti-mitotic therapies: can we improve on tubulin agents?

Authors:  Jeffrey R Jackson; Denis R Patrick; Mohammed M Dar; Pearl S Huang
Journal:  Nat Rev Cancer       Date:  2007-02       Impact factor: 60.716

4.  A short history of SHELX.

Authors:  George M Sheldrick
Journal:  Acta Crystallogr A       Date:  2007-12-21       Impact factor: 2.290

Review 5.  Microtubules, microtubule-interfering agents and apoptosis.

Authors:  F Mollinedo; C Gajate
Journal:  Apoptosis       Date:  2003-10       Impact factor: 4.677

6.  Taxol suppresses dynamics of individual microtubules in living human tumor cells.

Authors:  A M Yvon; P Wadsworth; M A Jordan
Journal:  Mol Biol Cell       Date:  1999-04       Impact factor: 4.138

7.  N-(2,6-dimethoxypyridine-3-yl)-9-methylcarbazole-3-sulfonamide as a novel tubulin ligand against human cancer.

Authors:  Yue-Ming Wang; Lai-Xing Hu; Zhen-Ming Liu; Xue-Fu You; Sheng-Hua Zhang; Jing-Rong Qu; Zhuo-Rong Li; Yan Li; Wei-Jia Kong; Hong-Wei He; Rong-Guang Shao; Liang-Ren Zhang; Zong-Gen Peng; David W Boykin; Jian-Dong Jiang
Journal:  Clin Cancer Res       Date:  2008-10-01       Impact factor: 12.531

8.  Structure validation in chemical crystallography.

Authors:  Anthony L Spek
Journal:  Acta Crystallogr D Biol Crystallogr       Date:  2009-01-20
  8 in total

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