BACKGROUND: The incidence of transfusion-related acute lung injury (TRALI) in adults is approximately one per 5000 transfusions. The Canadian Paediatric Surveillance Program undertook the present study to determine the incidence of TRALI in the paediatric population and to describe the characteristics and outcomes of children with TRALI. METHODS: The present surveillance study was conducted over a three-year period. RESULTS: Four TRALI cases were reported, yielding an incidence rate of 1.8 per 100,000 transfusions. The degree of severity varied: in two patients, only supplemental oxygen was necessary, while the other two required mechanical ventilation. CONCLUSION: TRALI was reported much less often in the present study compared with adult studies; therefore, it needs to be determined whether TRALI occurs less frequently in children, or alternatively, whether TRALI is recognized less often in children. The possibility that neonates who undergo cardiac surgery are at greater risk of TRALI than other patients should be addressed in future studies.
BACKGROUND: The incidence of transfusion-related acute lung injury (TRALI) in adults is approximately one per 5000 transfusions. The Canadian Paediatric Surveillance Program undertook the present study to determine the incidence of TRALI in the paediatric population and to describe the characteristics and outcomes of children with TRALI. METHODS: The present surveillance study was conducted over a three-year period. RESULTS: Four TRALI cases were reported, yielding an incidence rate of 1.8 per 100,000 transfusions. The degree of severity varied: in two patients, only supplemental oxygen was necessary, while the other two required mechanical ventilation. CONCLUSION: TRALI was reported much less often in the present study compared with adult studies; therefore, it needs to be determined whether TRALI occurs less frequently in children, or alternatively, whether TRALI is recognized less often in children. The possibility that neonates who undergo cardiac surgery are at greater risk of TRALI than other patients should be addressed in future studies.
Authors: H V New; S J Stanworth; C P Engelfriet; H W Reesink; Z K McQuilten; H F Savoia; E M Wood; S Olyntho; F Trigo; S Wendel; Y Lin; H Hume; J Petäjä; T Krusius; S Villa; S Ghirardello; J von Lindern; A Brand; J E Hendrickson; C D Josephson; R G Strauss; N L C Luban; W Paul Journal: Vox Sang Date: 2009-01 Impact factor: 2.144
Authors: Cassandra D Josephson; Leon L Su; Robert D Christensen; Christopher D Hillyer; Marta-Inés Castillejo; Michele R Emory; Yulia Lin; Heather Hume; Kirk Easley; Brandon Poterjoy; Martha Sola-Visner Journal: Pediatrics Date: 2009-01 Impact factor: 7.124
Authors: Allan Doctor; Jill M Cholette; Kenneth E Remy; Andrew Argent; Jeffrey L Carson; Stacey L Valentine; Scot T Bateman; Jacques Lacroix Journal: Pediatr Crit Care Med Date: 2018-09 Impact factor: 3.624
Authors: Pierre Demaret; Guillaume Emeriaud; Nabil E Hassan; Martin C J Kneyber; Stacey L Valentine; Scot T Bateman; Marisa Tucci Journal: Pediatr Crit Care Med Date: 2018-09 Impact factor: 3.624
Authors: Mohammod Jobayer Chisti; Mohammed Abdus Salam; Hasan Ashraf; Abu S G Faruque; Pradip Kumar Bardhan; Md Iqbal Hossain; Abu S M S B Shahid; K M Shahunja; Sumon Kumar Das; Gazi Imran; Tahmeed Ahmed Journal: PLoS One Date: 2013-09-09 Impact factor: 3.240