Literature DB >> 23632020

Structural diversity of eukaryotic membrane cytochrome p450s.

Eric F Johnson1, C David Stout.   

Abstract

X-ray crystal structures are available for 29 eukaryotic microsomal, chloroplast, or mitochondrial cytochrome P450s, including two non-monooxygenase P450s. These structures provide a basis for understanding structure-function relations that underlie their distinct catalytic activities. Moreover, structural plasticity has been characterized for individual P450s that aids in understanding substrate binding in P450s that mediate drug clearance.

Keywords:  Carcinogenesis; Cytochrome P450; Drug Development; Drug Metabolism; Protein structure; Steroidogenesis

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Year:  2013        PMID： 23632020      PMCID： PMC3682514          DOI： 10.1074/jbc.R113.452805

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  97 in total

1.  Structural analysis of mammalian cytochrome P450 2B4 covalently bound to the mechanism-based inactivator tert-butylphenylacetylene: insight into partial enzymatic activity.

Authors:  Sean C Gay; Haoming Zhang; P Ross Wilderman; Arthur G Roberts; Tong Liu; Sheng Li; Hsia-Lien Lin; Qinghai Zhang; Virgil L Woods; C David Stout; Paul F Hollenberg; James R Halpert
Journal:  Biochemistry       Date:  2011-05-13       Impact factor: 3.162

Review 2.  A review of mechanistic studies on aromatase (CYP19) and 17α-hydroxylase-17,20-lyase (CYP17).

Authors:  Muhammad Akhtar; J Neville Wright; Peter Lee-Robichaud
Journal:  J Steroid Biochem Mol Biol       Date:  2010-11-19       Impact factor: 4.292

3.  Potent mechanism-based inactivation of cytochrome P450 2B4 by 9-ethynylphenanthrene: implications for allosteric modulation of cytochrome P450 catalysis.

Authors:  Haoming Zhang; Sean C Gay; Manish Shah; Maryam Foroozesh; Jiawang Liu; Yoichi Osawa; Qinghai Zhang; C David Stout; James R Halpert; Paul F Hollenberg
Journal:  Biochemistry       Date:  2013-01-04       Impact factor: 3.162

4.  Structure and function of cytochromes P450 2B: from mechanism-based inactivators to X-ray crystal structures and back.

Authors:  James R Halpert
Journal:  Drug Metab Dispos       Date:  2011-04-18       Impact factor: 3.922

5.  Structure and function of an NADPH-cytochrome P450 oxidoreductase in an open conformation capable of reducing cytochrome P450.

Authors:  Djemel Hamdane; Chuanwu Xia; Sang-Choul Im; Haoming Zhang; Jung-Ja P Kim; Lucy Waskell
Journal:  J Biol Chem       Date:  2009-01-26       Impact factor: 5.157

6.  Structural insights into aldosterone synthase substrate specificity and targeted inhibition.

Authors:  Natallia Strushkevich; Andrei A Gilep; Limin Shen; Cheryl H Arrowsmith; Aled M Edwards; Sergey A Usanov; Hee-Won Park
Journal:  Mol Endocrinol       Date:  2013-01-15

7.  Crystal structure of CYP24A1, a mitochondrial cytochrome P450 involved in vitamin D metabolism.

Authors:  Andrew J Annalora; David B Goodin; Wen-Xu Hong; Qinghai Zhang; Eric F Johnson; C David Stout
Journal:  J Mol Biol       Date:  2009-12-01       Impact factor: 5.469

8.  Determinants of cytochrome P450 2C8 substrate binding: structures of complexes with montelukast, troglitazone, felodipine, and 9-cis-retinoic acid.

Authors:  Guillaume A Schoch; Jason K Yano; Stefaan Sansen; Patrick M Dansette; C David Stout; Eric F Johnson
Journal:  J Biol Chem       Date:  2008-04-15       Impact factor: 5.157

9.  Crystal structure of a cytochrome P450 2B6 genetic variant in complex with the inhibitor 4-(4-chlorophenyl)imidazole at 2.0-A resolution.

Authors:  Sean C Gay; Manish B Shah; Jyothi C Talakad; Keiko Maekawa; Arthur G Roberts; P Ross Wilderman; Ling Sun; Jane Y Yang; Stephanie C Huelga; Wen-Xu Hong; Qinghai Zhang; C David Stout; James R Halpert
Journal:  Mol Pharmacol       Date:  2010-01-08       Impact factor: 4.436

10.  X-ray structure of human aromatase reveals an androgen-specific active site.

Authors:  Debashis Ghosh; Jennifer Griswold; Mary Erman; Walter Pangborn
Journal:  J Steroid Biochem Mol Biol       Date:  2009-10-04       Impact factor: 4.292
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  48 in total

1.  Functional importance of a peripheral pocket in mammalian cytochrome P450 2B enzymes.

Authors:  Hyun-Hee Jang; Jingbao Liu; Ga-Young Lee; James R Halpert; P Ross Wilderman
Journal:  Arch Biochem Biophys       Date:  2015-08-28       Impact factor: 4.013

2.  Could tyrosine and tryptophan serve multiple roles in biological redox processes?

Authors:  Jay R Winkler; Harry B Gray
Journal:  Philos Trans A Math Phys Eng Sci       Date:  2015-03-13       Impact factor: 4.226

Review 3.  Correlating structure and function of drug-metabolizing enzymes: progress and ongoing challenges.

Authors:  Eric F Johnson; J Patrick Connick; James R Reed; Wayne L Backes; Manoj C Desai; Lianhong Xu; D Fernando Estrada; Jennifer S Laurence; Emily E Scott
Journal:  Drug Metab Dispos       Date:  2013-10-15       Impact factor: 3.922

4.  Research Resource: Correlating Human Cytochrome P450 21A2 Crystal Structure and Phenotypes of Mutations in Congenital Adrenal Hyperplasia.

Authors:  Pradeep S Pallan; Li Lei; Chunxue Wang; Michael R Waterman; F Peter Guengerich; Martin Egli
Journal:  Mol Endocrinol       Date:  2015-07-14

5.  Oxidation of endogenous N-arachidonoylserotonin by human cytochrome P450 2U1.

Authors:  Michal Siller; Sandeep Goyal; Francis K Yoshimoto; Yi Xiao; Shouzou Wei; F Peter Guengerich
Journal:  J Biol Chem       Date:  2014-02-21       Impact factor: 5.157

6.  Active-site differences between substrate-free and ritonavir-bound cytochrome P450 (CYP) 3A5 reveal plasticity differences between CYP3A5 and CYP3A4.

Authors:  Mei-Hui Hsu; Eric F Johnson
Journal:  J Biol Chem       Date:  2019-03-29       Impact factor: 5.157

7.  Structural and biophysical characterization of human cytochromes P450 2B6 and 2A6 bound to volatile hydrocarbons: analysis and comparison.

Authors:  Manish B Shah; P Ross Wilderman; Jingbao Liu; Hyun-Hee Jang; Qinghai Zhang; C David Stout; James R Halpert
Journal:  Mol Pharmacol       Date:  2015-01-13       Impact factor: 4.436

8.  The role of cytochrome P450 2B6 and 2B4 substrate access channel residues predicted based on crystal structures of the amlodipine complexes.

Authors:  Hyun-Hee Jang; Dmitri R Davydov; Ga-Young Lee; Chul-Ho Yun; James R Halpert
Journal:  Arch Biochem Biophys       Date:  2014-01-18       Impact factor: 4.013

9.  Human Cytochrome P450 21A2, the Major Steroid 21-Hydroxylase: STRUCTURE OF THE ENZYME·PROGESTERONE SUBSTRATE COMPLEX AND RATE-LIMITING C-H BOND CLEAVAGE.

Authors:  Pradeep S Pallan; Chunxue Wang; Li Lei; Francis K Yoshimoto; Richard J Auchus; Michael R Waterman; F Peter Guengerich; Martin Egli
Journal:  J Biol Chem       Date:  2015-04-08       Impact factor: 5.157

10.  Functional characterization of cytochromes P450 2B from the desert woodrat Neotoma lepida.

Authors:  P Ross Wilderman; Hyun-Hee Jang; Jael R Malenke; Mariam Salib; Elisabeth Angermeier; Sonia Lamime; M Denise Dearing; James R Halpert
Journal:  Toxicol Appl Pharmacol       Date:  2013-12-19       Impact factor: 4.219
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