Jwa-Kyung Kim1, Sun Ryoung Choi2, Myung Jin Choi3, Sung Gyun Kim1, Young Ki Lee3, Jung Woo Noh3, Hyung Jik Kim1, Young Rim Song4. 1. Department of Internal Medicine, Hallym University Sacred Heart Hospital, Anyang, Republic of Korea; Kidney Research Institute, Hallym University College of Medicine, Republic of Korea. 2. Department of Internal Medicine, Kangnam Sacred Heart Hospital, Seoul, Republic of Korea; Kidney Research Institute, Hallym University College of Medicine, Republic of Korea. 3. Department of Internal Medicine, Chuncheon Sacred Heart Hospital, Seoul, Republic of Korea; Kidney Research Institute, Hallym University College of Medicine, Republic of Korea. 4. Department of Internal Medicine, Hallym University Sacred Heart Hospital, Anyang, Republic of Korea; Kidney Research Institute, Hallym University College of Medicine, Republic of Korea. Electronic address: yrisong@hanmail.net.
Abstract
BACKGROUND & AIMS: We investigated the prevalence of sarcopenia in elderly patients with end-stage renal disease (ESRD) and its relationship with various markers of nutrition, cognitive function, depressive symptoms, inflammation and β2-microglobulin. METHODS: A cross-sectional study was conducted with 95 patients having ESRD aged over 50 years. Sarcopenia was defined as a decline in both muscle mass and strength. RESULTS: The mean age was 63.9 ± 10.0 years; 56.8% were men and 52.6% had diabetes. Sarcopenia was highly prevalent in elderly patients with ESRD (37.0% in men and 29.3% in women). Subjective Global Assessment (SGA), inflammatory markers and β2-microglobulin levels were significantly associated with sarcopenia, even after adjustment for age, gender, diabetes, and body mass index. Additionally, patients with depressive symptoms showed a higher risk of sarcopenia relative to those without depressive symptoms (odds ratio, OR = 6.87, 95% confidence interval, CI = 2.06-22.96) and sarcopenia was more likely to be present in patients with mild cognitive dysfunction (OR = 6.35, 95% CI = 1.62-34.96). CONCLUSIONS: Sarcopenia is highly prevalent in elderly patients with ESRD and is closely associated with SGA, inflammatory markers, β2-microglobulin, depression and cognitive dysfunction.
BACKGROUND & AIMS: We investigated the prevalence of sarcopenia in elderly patients with end-stage renal disease (ESRD) and its relationship with various markers of nutrition, cognitive function, depressive symptoms, inflammation and β2-microglobulin. METHODS: A cross-sectional study was conducted with 95 patients having ESRD aged over 50 years. Sarcopenia was defined as a decline in both muscle mass and strength. RESULTS: The mean age was 63.9 ± 10.0 years; 56.8% were men and 52.6% had diabetes. Sarcopenia was highly prevalent in elderly patients with ESRD (37.0% in men and 29.3% in women). Subjective Global Assessment (SGA), inflammatory markers and β2-microglobulin levels were significantly associated with sarcopenia, even after adjustment for age, gender, diabetes, and body mass index. Additionally, patients with depressive symptoms showed a higher risk of sarcopenia relative to those without depressive symptoms (odds ratio, OR = 6.87, 95% confidence interval, CI = 2.06-22.96) and sarcopenia was more likely to be present in patients with mild cognitive dysfunction (OR = 6.35, 95% CI = 1.62-34.96). CONCLUSIONS:Sarcopenia is highly prevalent in elderly patients with ESRD and is closely associated with SGA, inflammatory markers, β2-microglobulin, depression and cognitive dysfunction.
Authors: Samah Hayek; Todd M Gibson; Wendy M Leisenring; Jennifer L Guida; Maria Monica Gramatges; Philip J Lupo; Rebecca M Howell; Kevin C Oeffinger; Smita Bhatia; Kim Edelstein; Melissa M Hudson; Leslie L Robison; Paul C Nathan; Yutaka Yasui; Kevin R Krull; Gregory T Armstrong; Kirsten K Ness Journal: J Clin Oncol Date: 2019-12-04 Impact factor: 44.544
Authors: Naohito Isoyama; Abdul Rashid Qureshi; Carla Maria Avesani; Bengt Lindholm; Peter Bàràny; Olof Heimbürger; Tommy Cederholm; Peter Stenvinkel; Juan Jesús Carrero Journal: Clin J Am Soc Nephrol Date: 2014-07-29 Impact factor: 8.237
Authors: Anoop Sheshadri; Piyawan Kittiskulnam; Cynthia Delgado; Rebecca L Sudore; Jennifer C Lai; Kirsten L Johansen Journal: Am J Nephrol Date: 2021-05-12 Impact factor: 3.754