[Effect of smoking on diabetes mellitus and dyslipidemia (effect of smoking on glucose and lipid metabolism)].

Smoking is one of the important risk factors of cardiovascular disease. Its effects on arteriosclerotic diseases act not only directly but indirectly, by worsening control of blood pressure, lipid metabolism and glucose metabolism. And in patients with diabetes, it affects both macroangiopathy and diabetic microangiopathy(especially diabetic nephronpathy) adversely. Unfortunately, all effects and mechanisms of smoking on metabolic diseases are not yet unclear. But smoking cessation improves lipid metabolism and may improve glucose metabolism and may decrease risk of impaired glucose tolerance, type 2 diabetes, and diabetic microangiopathy. All patients with metabolic diseases must quit smoking for control of diseases and prevention of arteriosclerotic disease as soon as possible.