PURPOSE: To evaluate 12 patients with delayed or nonunion of bones treated with bone marrow injections. METHODS: 6 men and 6 women aged 15 to 70 (mean, 45) years underwent bone marrow injections for delayed union (n=2) or atrophic non-union (n=10) of the ulna (n=6), femur (n=3), humerus (n=2), or metacarpal (n=1). Bone marrow was aspirated from the anterior iliac crest and injected to the delayed and non-union sites. Two injections were given for children and adolescents, and 3 for adults. The interval between the injections was 6 to 8 weeks. The amount of bone marrow injected was 30 to 40 ml for long bones and 20 ml for metacarpals. RESULTS: Ten of the 12 delayed or non-union of bones healed after bone marrow injections. The mean time for callus formation was 5.8 (range, 3-10) weeks, for clinical union was 7 (range, 4-12) weeks, and for radiological union was 16 (range, 10-24) weeks. CONCLUSION: Multiple injections of low-volume bone marrow can be used for treatment of delayed or non-union of bones.
PURPOSE: To evaluate 12 patients with delayed or nonunion of bones treated with bone marrow injections. METHODS: 6 men and 6 women aged 15 to 70 (mean, 45) years underwent bone marrow injections for delayed union (n=2) or atrophic non-union (n=10) of the ulna (n=6), femur (n=3), humerus (n=2), or metacarpal (n=1). Bone marrow was aspirated from the anterior iliac crest and injected to the delayed and non-union sites. Two injections were given for children and adolescents, and 3 for adults. The interval between the injections was 6 to 8 weeks. The amount of bone marrow injected was 30 to 40 ml for long bones and 20 ml for metacarpals. RESULTS: Ten of the 12 delayed or non-union of bones healed after bone marrow injections. The mean time for callus formation was 5.8 (range, 3-10) weeks, for clinical union was 7 (range, 4-12) weeks, and for radiological union was 16 (range, 10-24) weeks. CONCLUSION: Multiple injections of low-volume bone marrow can be used for treatment of delayed or non-union of bones.
Entities:
Keywords:
bone marrow; bone matrix; injections; platelet-rich plasma
Authors: Louis-Romée Le Nail; Julien Stanovici; Joseph Fournier; Marie Splingard; Jorge Domenech; Philippe Rosset Journal: Int Orthop Date: 2014-04-13 Impact factor: 3.075
Authors: Frederico C Vallim; João Antonio Matheus Guimarães; Rhayra B Dias; Rafaela C Sartore; Amanda Dos S Cavalcanti; Ana C Leal; Maria Eugenia L Duarte; Danielle C Bonfim Journal: OTA Int Date: 2018-12-18