Literature DB >> 23628972

Shortened blood coagulation times in genetically obese rats and diet-induced obese mice.

Noriyuki Kaji1, Dai Nagakubo, Shin-Ichi Hashida, Saya Takahashi, Motoi Kuratani, Norihiko Hirai, Mitsuyuki Shirai, Fumitoshi Asai.   

Abstract

The aim of this study was to investigate blood coagulation times in genetically obese rats and diet-induced obese (DIO) mice in order to clarify the relationship between visceral obesity and blood coagulation. WBN/Kob-Lepr(fa) (fa/fa) rats, a genetically obese model, exhibited a significantly shorter activated partial thromboplastin time (aPTT) and prothrombin time (PT) than age-matched Wistar rats. C57BL/6J mice fed a high-fat diet (60%), a DIO model, exhibited significantly shorter aPTT, PT and thrombin time than lean mice fed a standard diet. Higher body weight, visceral fat weight and insulin resistance were also shared by fa/fa rats and DIO mice. These results suggest that visceral obesity is related to accelerated blood coagulation in addition to disrupted metabolism of glucose and lipids.

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Year:  2013        PMID： 23628972     DOI： 10.1292/jvms.13-0029

Source DB:  PubMed          Journal:  J Vet Med Sci        ISSN： 0916-7250            Impact factor:   1.267


  6 in total

1.  Changes in Dietary Fat Content Rapidly Alters the Mouse Plasma Coagulation Profile without Affecting Relative Transcript Levels of Coagulation Factors.

Authors:  Audrey C A Cleuren; Vicky T Blankevoort; Janna A van Diepen; Daniël Verhoef; Peter J Voshol; Pieter H Reitsma; Bart J M van Vlijmen
Journal:  PLoS One       Date:  2015-07-15       Impact factor: 3.240

2.  Intraoperative hyperglycemia during liver resection: predictors and association with the extent of hepatocytes injury.

Authors:  Sangbin Han; Justin Sangwook Ko; Sang-Man Jin; Hyo-Won Park; Jong Man Kim; Jae-Won Joh; Gaabsoo Kim; Soo Joo Choi
Journal:  PLoS One       Date:  2014-10-08       Impact factor: 3.240

3.  Plasma markers of inflammation and hemostatic and endothelial activity in naturally overweight and obese dogs.

Authors:  R Barić Rafaj; J Kuleš; A Marinculić; A Tvarijonaviciute; J Ceron; Ž Mihaljević; A Tumpa; V Mrljak
Journal:  BMC Vet Res       Date:  2017-01-06       Impact factor: 2.741

4.  Modulation of Blood Coagulation and Hematological Parameters by Crassocephalum crepidioides Leaf Methanol Extract and Fractions in STZ-Induced Diabetes in the Rat.

Authors:  Opeyemi O Ayodele; Funmilayo D Onajobi; Omolaja R Osoniyi
Journal:  ScientificWorldJournal       Date:  2020-05-15

Review 5.  Thromboinflammatory Processes at the Nexus of Metabolic Dysfunction and Prostate Cancer: The Emerging Role of Periprostatic Adipose Tissue.

Authors:  Ibrahim AlZaim; Aya Al-Saidi; Safaa H Hammoud; Nadine Darwiche; Yusra Al-Dhaheri; Ali H Eid; Ahmed F El-Yazbi
Journal:  Cancers (Basel)       Date:  2022-03-25       Impact factor: 6.639

6.  Effects of different diets used in diet-induced obesity models on insulin resistance and vascular dysfunction in C57BL/6 mice.

Authors:  Philipp Lang; Solveig Hasselwander; Huige Li; Ning Xia
Journal:  Sci Rep       Date:  2019-12-20       Impact factor: 4.379
  6 in total

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