OBJECTIVE: Neutrophil gelatinase-associated lipocalin (NGAL) is secreted by injured kidney cells as well as by activated neutrophils in response to bacterial infections. We assessed the influence of acute renal dysfunction on the association between plasma NGAL and sepsis. METHODS: NGAL was measured daily in 138 critically ill patients. Simultaneous recordings of sepsis status and fluctuations in renal function were made. RESULTS: Elevated NGAL was associated with sepsis independent of level of acute renal dysfunction. A cut-off value of 98 ng/mL distinguished sepsis from systemic inflammation with high sensitivity (0.77) and specificity (0.79). CONCLUSIONS: Plasma NGAL can help clinicians to identify bacterial infections in critically ill patients.
OBJECTIVE:Neutrophil gelatinase-associated lipocalin (NGAL) is secreted by injured kidney cells as well as by activated neutrophils in response to bacterial infections. We assessed the influence of acute renal dysfunction on the association between plasma NGAL and sepsis. METHODS:NGAL was measured daily in 138 critically illpatients. Simultaneous recordings of sepsis status and fluctuations in renal function were made. RESULTS: Elevated NGAL was associated with sepsis independent of level of acute renal dysfunction. A cut-off value of 98 ng/mL distinguished sepsis from systemic inflammation with high sensitivity (0.77) and specificity (0.79). CONCLUSIONS: Plasma NGAL can help clinicians to identify bacterial infections in critically illpatients.
Authors: Fang Yu; Aisha Saand; Changhong Xing; Jong Woo Lee; Liangge Hsu; Octavia P Palmer; Vanessa Jackson; Lu Tang; MingMing Ning; Rose Du; Patrick M Kochanek; Eng H Lo; Sherry H-Y Chou Journal: J Cereb Blood Flow Metab Date: 2021-05-05 Impact factor: 6.200
Authors: Johan Mårtensson; Niklas Jonsson; Neil J Glassford; Max Bell; Claes-Roland Martling; Rinaldo Bellomo; Anders Larsson Journal: Ann Intensive Care Date: 2016-01-13 Impact factor: 6.925