INTRODUCTION: The dystrophic features in hindlimb skeletal muscles of female mdx mice are unclear. METHODS: We analyzed force-generating capacity and force decline after lengthening contraction-induced damage (fragility). RESULTS: Young (6-month-old) female mdx mice displayed reduced force-generating capacity (-18%) and higher fragility (23% force decline) compared with female age-matched wild-type mice. These 2 dystrophic features were less accentuated in young female than in young male mdx mice (-32% and 42% force drop). With advancing age, force-generating capacity decreased and fragility increased in old (20 month) female mdx mice (-21% and 57% force decline), but they were unchanged in old male mdx mice. Moreover, estradiol treatment had no effect in old female mdx mice. CONCLUSIONS: Female gender-related factors mitigate dystrophic features in young but not old mdx mice. Further studies are warranted to identify the beneficial gender-related factor in dystrophic muscle.
INTRODUCTION: The dystrophic features in hindlimb skeletal muscles of female mdx mice are unclear. METHODS: We analyzed force-generating capacity and force decline after lengthening contraction-induced damage (fragility). RESULTS: Young (6-month-old) female mdx mice displayed reduced force-generating capacity (-18%) and higher fragility (23% force decline) compared with female age-matched wild-type mice. These 2 dystrophic features were less accentuated in young female than in young male mdx mice (-32% and 42% force drop). With advancing age, force-generating capacity decreased and fragility increased in old (20 month) female mdx mice (-21% and 57% force decline), but they were unchanged in old male mdx mice. Moreover, estradiol treatment had no effect in old female mdx mice. CONCLUSIONS: Female gender-related factors mitigate dystrophic features in young but not old mdx mice. Further studies are warranted to identify the beneficial gender-related factor in dystrophic muscle.
Authors: Allison M Kosir; Tara L Mader; Angela G Greising; Susan A Novotny; Kristen A Baltgalvis; Dawn A Lowe Journal: Med Sci Sports Exerc Date: 2015-06 Impact factor: 5.411
Authors: Pangdra Vang; Cory W Baumann; Rebecca Barok; Alexie A Larson; Brendan J Dougherty; Dawn A Lowe Journal: PLoS One Date: 2021-03-31 Impact factor: 3.240