| Literature DB >> 2362548 |
I H Hall1, J P Scoville, D J Reynolds, R Simlot, P Duncan.
Abstract
N-substituted cyclic imides of phthalimide, 2,3-dihydrohalazine-1,4-dione, and diphenimide were shown to reduce the serum uric acid levels in normal and hyperuric mice at 20 mg/kg/day I.P. for 14 days. The agents were potent inhibitors of commercial xanthine dehydrogenase and xanthine oxidase enzyme activities with IC50 values from 10(-7) to 10(-8) M concentrations of drug.Entities:
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Year: 1990 PMID： 2362548 DOI： 10.1016/0024-3205(90)90507-n
Source DB: PubMed Journal: Life Sci ISSN： 0024-3205 Impact factor: 5.037