Literature DB >> 23623491

Synthesis of pyrazolo[1,5-a]pyrimidine linked aminobenzothiazole conjugates as potential anticancer agents.

Ahmed Kamal1, Jaki R Tamboli, V Lakshma Nayak, S F Adil, M V P S Vishnuvardhan, S Ramakrishna.   

Abstract

A series of pyrazolo[1,5-a]pyrimidine linked 2-aminobenzothizole conjugates (6a-t) were synthesized and evaluated for their anticancer activity against five human cancer cell lines. Among them two compounds 6p and 6m showed significant anticancer activity with IC50 values ranging from 2.01 to 7.07 and 1.94-3.46 μM, respectively. Moreover, cell cycle arrest in G2/M and reduction in Cdk1 expression level were observed upon treatment of these compounds and they also induced caspase-3 dependent apoptosis. This was further confirmed by staining as well as DNA fragmentation analysis.
Copyright © 2013. Published by Elsevier Ltd.

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Year:  2013        PMID： 23623491     DOI： 10.1016/j.bmcl.2013.03.129

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  9 in total

1.  Benzimidazole-linked pyrazolo[1,5-a]pyrimidine conjugates: synthesis and detail evaluation as potential anticancer agents.

Authors:  Chandrakant Bagul; Garikapati Koteswara Rao; Immadi Veena; Ravindra Kulkarni; Jaki R Tamboli; Ravikumar Akunuri; Siddiq Pasha Shaik; Manika Pal-Bhadra; Ahmed Kamal
Journal:  Mol Divers       Date:  2022-09-17       Impact factor: 3.364

2.  Efficient microwave-assisted Suzuki-Miyaura cross-coupling reaction of 3-bromo pyrazolo[1,5-a]pyrimidin-5(4H)-one: towards a new access to 3,5-diarylated 7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine derivatives.

Authors:  Badr Jismy; Gérald Guillaumet; Mohamed Akssira; Abdellatif Tikad; Mohamed Abarbri
Journal:  RSC Adv       Date:  2021-01-04       Impact factor: 4.036

3.  Synthesis and biological evaluation of chalcone-linked pyrazolo[1,5-a]pyrimidines as potential anticancer agents.

Authors:  Chandrakant Bagul; Garikapati Koteswara Rao; Venkata Krishna Kanth Makani; Jaki R Tamboli; Manika Pal-Bhadra; Ahmed Kamal
Journal:  Medchemcomm       Date:  2017-07-13       Impact factor: 3.597

Review 4.  5-Aminopyrazole as precursor in design and synthesis of fused pyrazoloazines.

Authors:  Ranjana Aggarwal; Suresh Kumar
Journal:  Beilstein J Org Chem       Date:  2018-01-25       Impact factor: 2.883

5.  Efficient Access to 3,5-Disubstituted 7-(Trifluoromethyl)pyrazolo[1,5-a]pyrimidines Involving SNAr and Suzuki Cross-Coupling Reactions.

Authors:  Badr Jismy; Abdellatif Tikad; Mohamed Akssira; Gérald Guillaumet; Mohamed Abarbri
Journal:  Molecules       Date:  2020-04-28       Impact factor: 4.411

Review 6.  Importance of Fluorine in Benzazole Compounds.

Authors:  Thuraya Al-Harthy; Wajdi Zoghaib; Raid Abdel-Jalil
Journal:  Molecules       Date:  2020-10-14       Impact factor: 4.411

7.  Synthesis and Toxicological Effect of Some New Pyrrole Derivatives as Prospective Insecticidal Agents against the Cotton Leafworm, Spodoptera littoralis (Boisduval).

Authors:  Antar A Abdelhamid; Kaoud S M Salama; Ahmed M Elsayed; Mohamed A Gad; Mahmoud Abd El Aleem Ali Ali El-Remaily
Journal:  ACS Omega       Date:  2022-01-25

8.  Synthesis, Characterization, and Cytotoxicity of Some New 5-Aminopyrazole and Pyrazolo[1,5-a]pyrimidine Derivatives.

Authors:  Ashraf S Hassan; Taghrid S Hafez; Souad A Osman
Journal:  Sci Pharm       Date:  2014-10-24

9.  Apoptosis inducing ability of silver decorated highly reduced graphene oxide nanocomposites in A549 lung cancer.

Authors:  Merajuddin Khan; Mujeeb Khan; Abdulhadi H Al-Marri; Abdulrahman Al-Warthan; Hamad Z Alkhathlan; Mohammed Rafiq H Siddiqui; Vadithe Lakshma Nayak; Ahmed Kamal; Syed F Adil
Journal:  Int J Nanomedicine       Date:  2016-03-07
  9 in total

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