OBJECTIVE: This study investigated the effect of fresh garlic aqueous extract on glomerular glycation in streptozotocin-induced diabetic rats. METHOD: Serum insulin and glucose, in addition to renal corpuscles and erythrocyte hemoglobin glycation were determined in normal saline-treated normal rats (NS-NR), normal saline-treated diabetic rats (NS-DR) and garlic-treated diabetic rats (G-DR). RESULTS: Compared to NS-NR, NS-DR showed significant decrease in serum insulin and increase in serum glucose and hemoglobin glycation. NS-DR also showed intense, diffused glomerular periodic acid Schiff activity. Compared to NS-DR, G-DR showed significant increase in serum insulin and decrease in serum glucose and hemoglobin glycation. Furthermore, the G-DR glomerular periodic acid Schiff activity and distribution was almost restored to that observed in NS-NR. CONCLUSION: Garlic may attenuate glomerular glycation in streptozotocin-induced diabetic rats. This effect could be partially mediated via euglycemia induced by revitalization of endogenous insulin.
OBJECTIVE: This study investigated the effect of fresh garlic aqueous extract on glomerular glycation in streptozotocin-induced diabeticrats. METHOD: Serum insulin and glucose, in addition to renal corpuscles and erythrocyte hemoglobin glycation were determined in normal saline-treated normal rats (NS-NR), normal saline-treated diabeticrats (NS-DR) and garlic-treated diabeticrats (G-DR). RESULTS: Compared to NS-NR, NS-DR showed significant decrease in serum insulin and increase in serum glucose and hemoglobin glycation. NS-DR also showed intense, diffused glomerular periodic acid Schiff activity. Compared to NS-DR, G-DR showed significant increase in serum insulin and decrease in serum glucose and hemoglobin glycation. Furthermore, the G-DR glomerular periodic acid Schiff activity and distribution was almost restored to that observed in NS-NR. CONCLUSION:Garlic may attenuate glomerular glycation in streptozotocin-induced diabeticrats. This effect could be partially mediated via euglycemia induced by revitalization of endogenous insulin.
Authors: José Pedraza-Chaverri; Laura G Sánchez-Lozada; Horacio Osorio-Alonso; Edilia Tapia; Alexandra Scholze Journal: Oxid Med Cell Longev Date: 2016-06-27 Impact factor: 6.543
Authors: Khaled K Al-Qattan; Martha Thomson; Divya Jayasree; Muslim Ali Journal: Evid Based Complement Alternat Med Date: 2016-05-18 Impact factor: 2.629