BACKGROUND: Abruptio placentae is a serious problem with a high rate of maternal and fetal mortality and documented sexual dimorphism in reoccurrence. Macaca fascicularis is a well-described reproductive model; however, there are no data available regarding sexual dimorphism in abruptio placentae in these species. METHODS: A retrospective study of pathology and medical records in a large colony of M. fascicularis was performed. Placental specimens were analyzed. RESULTS: The incidence of placenta abruptio in the colony was 15.7/1000 births. In the abruptio placentae group, male fetuses had lower placental disk length and increased femur length compared with female fetuses. The feto-pacental ratio and fetal weight were lower in the male fetuses in the abruption group compared with those in the stillbirth group without abruption placentae. CONCLUSION: This is the first documentation of male bias in placental and fetal development in abruptio placentae in non-human primates.
BACKGROUND: Abruptio placentae is a serious problem with a high rate of maternal and fetal mortality and documented sexual dimorphism in reoccurrence. Macaca fascicularis is a well-described reproductive model; however, there are no data available regarding sexual dimorphism in abruptio placentae in these species. METHODS: A retrospective study of pathology and medical records in a large colony of M. fascicularis was performed. Placental specimens were analyzed. RESULTS: The incidence of placenta abruptio in the colony was 15.7/1000 births. In the abruptio placentae group, male fetuses had lower placental disk length and increased femur length compared with female fetuses. The feto-pacental ratio and fetal weight were lower in the male fetuses in the abruption group compared with those in the stillbirth group without abruption placentae. CONCLUSION: This is the first documentation of male bias in placental and fetal development in abruptio placentae in non-human primates.
Authors: Jiude Mao; Xia Zhang; Paizlee T Sieli; Michael T Falduto; Karen E Torres; Cheryl S Rosenfeld Journal: Proc Natl Acad Sci U S A Date: 2010-03-08 Impact factor: 11.205
Authors: Minna Tikkanen; Marjo Metsäranta; Mika Gissler; Tiina Luukkaala; Vilho Hiilesmaa; Olavi Ylikorkala; Jorma Paavonen; Sture Andersson; Mika Nuutila Journal: Acta Obstet Gynecol Scand Date: 2010-07 Impact factor: 3.636
Authors: Minna Tikkanen; Mika Gissler; Marjo Metsäranta; Tiina Luukkaala; Vilho Hiilesmaa; Sture Andersson; Olavi Ylikorkala; Jorma Paavonen; Mika Nuutila Journal: Acta Obstet Gynecol Scand Date: 2009 Impact factor: 3.636