Literature DB >> 23621186

Identification of serum microRNA-21 as a biomarker for early detection and prognosis in human epithelial ovarian cancer.

Yun-Zhao Xu1, Qing-Hua Xi, Wen-Liang Ge, Xiao-Qian Zhang.   

Abstract

Recent investigations have confirmed up-regulation of serum miR-21 and its diagnostic and prognostic value in several human malignancies. In this study, we examined serum miR-21 levels in epithelial ovarian cancer (EOC) patients, and explored its association with clinicopathological factors and prognosis. The results showed significantly higher serum miR-21 levels in EOC patients than in healthy controls. In addition, increased serum miR-21 expression was correlated with advanced FIGO stage, high tumor grade, and shortened overall survival. These findings indicate that serum miR-21 may serve as a novel diagnostic and prognostic marker, and be used as a therapeutic target for the treatment of EOC.

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Year:  2013        PMID： 23621186     DOI： 10.7314/apjcp.2013.14.2.1057

Source DB:  PubMed          Journal:  Asian Pac J Cancer Prev        ISSN： 1513-7368


  33 in total

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Review 2.  Circulating biomarkers in epithelial ovarian cancer diagnosis: from present to future perspective.

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Review 3.  Regulation of cancer metastasis by cell-free miRNAs.

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Journal:  Tumour Biol       Date:  2016-01-05

Review 6.  Biological markers of prognosis, response to therapy and outcome in ovarian carcinoma.

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Review 7.  Clinical relevance of circulating cell-free microRNAs in cancer.

Authors:  Heidi Schwarzenbach; Naohiro Nishida; George A Calin; Klaus Pantel
Journal:  Nat Rev Clin Oncol       Date:  2014-02-04       Impact factor: 66.675

8.  Evaluation of miR-22 and miR-21 as diagnostic biomarkers in patients with epithelial ovarian cancer.

Authors:  Nidhi Paliwal; Minakshi Vashist; Minakshi Chauhan
Journal:  3 Biotech       Date:  2020-02-27       Impact factor: 2.406

Review 9.  Challenges of deciphering gastric cancer heterogeneity.

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10.  Prognostic role of circulating microRNA-21 in cancers: evidence from a meta-analysis.

Authors:  Yinlong Yang; Jinxian Qian; Yizuo Chen; Yifei Pan
Journal:  Tumour Biol       Date:  2014-03-25
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