T Liu1, Y Han, L Lu.
Abstract
BACKGROUND: The gene coding for angiotensin-converting enzyme (ACE) has been reported to be associated with the development of psoriasis. AIM: To evaluate the association of psoriasis risk and ACE polymorphisms.
METHODS: We carried out a retrieval of studies that explored associations between ACE polymorphism and psoriasis, and analysed the genotype frequencies.
RESULTS: In total, 8 studies with 1242 patients and 1646 controls were included. The genotype frequencies in all studies were in Hardy-Weinberg equilibrium. After pooling all studies, the results indicated that the I/I genotype was associated with risk of psoriasis (OR = 1.41, 95% CI 1.11-1.80, P = 0.005), whereas the I/D genotype may decrease the risk of psoriasis (OR = 0.71, 95% CI 0.56-0.90, P = 0.005) in Asian, but not in white populations.
CONCLUSIONS: Our study suggests that ACE polymorphism are associated with the risk of psoriasis in Asians, especially the I/I genotype and I allele. Further studies are needed to confirm our results. © The Author(s) CED
BACKGROUND: The gene coding for angiotensin-converting enzyme (ACE) has been reported to be associated with the development of psoriasis. AIM: To evaluate the association of psoriasis risk and ACE polymorphisms.
METHODS: We carried out a retrieval of studies that explored associations between ACE polymorphism and psoriasis, and analysed the genotype frequencies.
RESULTS: In total, 8 studies with 1242 patients and 1646 controls were included. The genotype frequencies in all studies were in Hardy-Weinberg equilibrium. After pooling all studies, the results indicated that the I/I genotype was associated with risk of psoriasis (OR = 1.41, 95% CI 1.11-1.80, P = 0.005), whereas the I/D genotype may decrease the risk of psoriasis (OR = 0.71, 95% CI 0.56-0.90, P = 0.005) in Asian, but not in white populations.
CONCLUSIONS: Our study suggests that ACE polymorphism are associated with the risk of psoriasis in Asians, especially the I/I genotype and I allele. Further studies are needed to confirm our results. © The Author(s) CED
© 2013 British Association of Dermatologists.
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Year: 2013
PMID： 23621089 DOI： 10.1111/ced.12106
Source DB: PubMed Journal: Clin Exp Dermatol ISSN： 0307-6938 Impact factor: 3.470