Isomer-selective thermal activation of methane in the gas phase by [HMO]+ and [M(OH)]+ (M=Ti and V).

Methane scrabble: To have the right elements is sometimes just not sufficient, as shown by [M(OH)](+) (M=Ti, V), which do not react with methane. However, reshuffling of the "tiles" to [HMO](+) changes the reactions behavior completely, leading to the first example of C-H bond activation of methane by an early first-row transition-metal cation.