Literature DB >> 23619945

Polymorphisms in DNA repair pathway genes, body mass index, and risk of non-Hodgkin lymphoma.

Yingtai Chen1, Tongzhang Zheng, Qing Lan, Christopher Kim, Qin Qin, Francine Foss, Xuezhong Chen, Theodore Holford, Brian Leaderer, Peter Boyle, Chengfeng Wang, Min Dai, Zhenjiang Liu, Shuangge Ma, Stephen J Chanock, Nathaniel Rothman, Yawei Zhang.   

Abstract

We conducted a population-based case-control study in Connecticut women to test the hypothesis that genetic variations in DNA repair pathway genes may modify the relationship between body mass index (BMI) and risk of non-Hodgkin lymphoma (NHL). Compared to those with BMI <25, women with BMI ≥25 had significantly increased risk of NHL among women who carried BRCA1 (rs799917) CT/TT, ERCC2 (rs13181) AA, XRCC1 (rs1799782) CC, and WRN (rs1801195) GG genotypes, but no increase in NHL risk among women who carried BRCA1 CC, ERCC2 AC/CC, XRCC1 CT/TT, and WRN GT/TT genotypes. A significant interaction with BMI was only observed for WRN (rs1801195; P = 0.004) for T-cell lymphoma and ERCC2 (rs13181; P = 0.002) for diffuse large B-cell lymphoma. The results suggest that common genetic variation in DNA repair pathway genes may modify the association between BMI and NHL risk.
Copyright © 2013 Wiley Periodicals, Inc.

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Year:  2013        PMID： 23619945      PMCID： PMC3902049          DOI： 10.1002/ajh.23463

Source DB:  PubMed          Journal:  Am J Hematol        ISSN： 0361-8609            Impact factor:   10.047


  49 in total

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3.  Polymorphisms in DNA repair genes and risk of non-Hodgkin lymphoma in a pooled analysis of three studies.

Authors:  Min Shen; Idan Menashe; Lindsay M Morton; Yawei Zhang; Bruce Armstrong; Sophia S Wang; Qing Lan; Patricia Hartge; Mark P Purdue; James R Cerhan; Andrew Grulich; Wendy Cozen; Meredith Yeager; Theodore R Holford; Claire M Vajdic; Scott Davis; Brian Leaderer; Anne Kricker; Richard K Severson; Shelia H Zahm; Nilanjan Chatterjee; Nathaniel Rothman; Stephen J Chanock; Tongzhang Zheng
Journal:  Br J Haematol       Date:  2010-08-31       Impact factor: 6.998

Review 4.  Recurring chromosomal abnormalities in non-Hodgkin's lymphoma: biologic and clinical significance.

Authors:  R S Chaganti; G Nanjangud; H Schmidt; J Teruya-Feldstein
Journal:  Semin Hematol       Date:  2000-10       Impact factor: 3.851

5.  Werner helicase relocates into nuclear foci in response to DNA damaging agents and co-localizes with RPA and Rad51.

Authors:  S Sakamoto; K Nishikawa; S J Heo; M Goto; Y Furuichi; A Shimamoto
Journal:  Genes Cells       Date:  2001-05       Impact factor: 1.891

6.  Oxidative DNA damage and obesity in type 2 diabetes mellitus.

Authors:  Hayder A Al-Aubaidy; Herbert F Jelinek
Journal:  Eur J Endocrinol       Date:  2011-03-24       Impact factor: 6.664

7.  Nuclear damage in peripheral lymphocytes of obese and overweight Italian children as evaluated by the gamma-H2AX focus assay and micronucleus test.

Authors:  Roberto Scarpato; Carmela Verola; Barbara Fabiani; Vanessa Bianchi; Giuseppe Saggese; Giovanni Federico
Journal:  FASEB J       Date:  2010-11-10       Impact factor: 5.191

8.  Non-Hodgkin lymphoma and obesity: a pooled analysis from the InterLymph Consortium.

Authors:  Eleanor V Willett; Lindsay M Morton; Patricia Hartge; Nikolaus Becker; Leslie Bernstein; Paolo Boffetta; Paige Bracci; James Cerhan; Brian C-H Chiu; Pierluigi Cocco; Luigino Dal Maso; Scott Davis; Silvia De Sanjose; Karin Ekstrom Smedby; Maria Grazia Ennas; Lenka Foretova; Elizabeth A Holly; Carlo La Vecchia; Keitaro Matsuo; Marc Maynadie; Mads Melbye; Eva Negri; Alexandra Nieters; Richard Severson; Susan L Slager; John J Spinelli; Anthony Staines; Renato Talamini; Martine Vornanen; Dennis D Weisenburger; Eve Roman
Journal:  Int J Cancer       Date:  2008-05-01       Impact factor: 7.396

9.  Polymorphisms in the nucleotide excision repair gene ERCC2/XPD and risk of non-Hodgkin lymphoma.

Authors:  Lisa Worrillow; Eve Roman; Peter J Adamson; Eleanor Kane; James M Allan; Tracy J Lightfoot
Journal:  Cancer Epidemiol       Date:  2009-09-06       Impact factor: 2.984

10.  WRN polymorphisms affect expression levels of plasminogen activator inhibitor type 1 in cultured fibroblasts.

Authors:  Elena Castro; Vladimir Oviedo-Rodríguez; Luis I Angel-Chávez
Journal:  BMC Cardiovasc Disord       Date:  2008-02-29       Impact factor: 2.298
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  5 in total

Review 1.  Association between BRCA1 P871L polymorphism and cancer risk: evidence from a meta-analysis.

Authors:  Limin Miao; Yang Yu; Yefeng Ji; Bo Zhang; Zhiyao Yuan; Yifei Du; Longbiao Zhu; Ruixia Wang; Ning Chen; Hua Yuan
Journal:  Oncotarget       Date:  2017-05-02

Review 2.  Association of the Asp312Asn and Lys751Gln polymorphisms in the XPD gene with the risk of non-Hodgkin's lymphoma: evidence from a meta-analysis.

Authors:  Shen Chen; Jin-Hong Zhu; Fang Wang; Shao-Yi Huang; Wen-Qiong Xue; Zhuo Cui; Jing He; Wei-Hua Jia
Journal:  Chin J Cancer       Date:  2015-03-05

3.  Novel Associations between BRCA1 Variants C.181 T>G (Rs28897672) and Ovarian Crisk in Saudi Females.

Authors:  Nora Alyahri; Saba Abdi; Wajahatullah Khan; Mohamed Elrobh; Mohammed H Addar; Zeneb A Babay; Mohamed Alanazi; Sooad Aldaihan; Jilani Shaik; Maha Arafah; Narasimha Reddy Parine; Arjumand Warsy
Journal:  J Med Biochem       Date:  2019-03-01       Impact factor: 3.402

4.  Novel Germline Mutation of BRCA1 Gene in a 56-Year-Old Woman with Breast Cancer, Ovarian Cancer, and Diffuse Large B-Cell Lymphoma.

Authors:  Hye Sook Kim; Soon Wook Lee; Yoon Ji Choi; Sang Won Shin; Yeul Hong Kim; Min Sun Cho; Soon Nam Lee; Kyong Hwa Park
Journal:  Cancer Res Treat       Date:  2014-10-17       Impact factor: 4.679

5.  Association of ERCC2 Gene Polymorphisms with Susceptibility to Diffuse Large B-Cell Lymphoma.

Authors:  Yong Tong; Yinzhou Xiang; Bao Li; Shijie Bao; Ying Zhou; Wen Yuan; Yu Ling; Dan Hao; Huamin Zhu; Zhiqiang Sun
Journal:  Med Sci Monit       Date:  2018-10-03
  5 in total

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