OBJECTIVE: The main aim of this prospective study was to explore the ability of the oral microbiome to produce acetaldehyde in ethanol incubation. STUDY DESIGN: A total of 90 patients [30 oral squamous cell carcinoma (OSCC); 30 oral lichenoid disease (OLD); 30 healthy controls (CO)] were enrolled in the study. Microbial samples were taken from the mucosa using a filter paper method. The density of microbial colonization was calculated and the spectrum analyzed. Microbial acetaldehyde production was measured by gas chromatography. RESULTS: The majority (68%) of cultures produced carcinogenic levels of acetaldehyde (>100 μM) when incubated with ethanol (22 mM). The mean acetaldehyde production by microbes cultured from smoker samples was significantly higher (213 μM) than from non-smoker samples (141 μM) (P=.0326). CONCLUSIONS: The oral microbiota from OSCC, OLD patients and healthy individuals are able to produce carcinogenic levels of acetaldehyde. The present provisional study suggests smoking may increase the production of acetaldehyde.
OBJECTIVE: The main aim of this prospective study was to explore the ability of the oral microbiome to produce acetaldehyde in ethanol incubation. STUDY DESIGN: A total of 90 patients [30 oral squamous cell carcinoma (OSCC); 30 oral lichenoid disease (OLD); 30 healthy controls (CO)] were enrolled in the study. Microbial samples were taken from the mucosa using a filter paper method. The density of microbial colonization was calculated and the spectrum analyzed. Microbial acetaldehyde production was measured by gas chromatography. RESULTS: The majority (68%) of cultures produced carcinogenic levels of acetaldehyde (>100 μM) when incubated with ethanol (22 mM). The mean acetaldehyde production by microbes cultured from smoker samples was significantly higher (213 μM) than from non-smoker samples (141 μM) (P=.0326). CONCLUSIONS: The oral microbiota from OSCC, OLD patients and healthy individuals are able to produce carcinogenic levels of acetaldehyde. The present provisional study suggests smoking may increase the production of acetaldehyde.
Authors: C P Furquim; G M S Soares; L L Ribeiro; M A Azcarate-Peril; N Butz; J Roach; K Moss; C Bonfim; C C Torres-Pereira; F R F Teles Journal: J Dent Res Date: 2016-11-13 Impact factor: 6.116
Authors: Koji Tanaka; Kelly A Whelan; Prasanna M Chandramouleeswaran; Shingo Kagawa; Sabrina L Rustgi; Chiaki Noguchi; Manti Guha; Satish Srinivasan; Yusuke Amanuma; Shinya Ohashi; Manabu Muto; Andres J Klein-Szanto; Eishi Noguchi; Narayan G Avadhani; Hiroshi Nakagawa Journal: Am J Cancer Res Date: 2016-03-15 Impact factor: 6.166
Authors: Mikko T Nieminen; Lily Novak-Frazer; Vilma Rautemaa; Ranjith Rajendran; Timo Sorsa; Gordon Ramage; Paul Bowyer; Riina Rautemaa Journal: PLoS One Date: 2014-05-27 Impact factor: 3.240