INTRODUCTION: It is known that patients with chronic hepatitis C have a lower health-related quality of life (HRQOL) than the general population and evidence suggests that the hepatitis C virus (HCV) could exert direct neuropathic action on HRQOL. From this perspective, the virus clearance should be accompanied by improvement in HRQOL. Thus, we sought to review systematically the evidence in the literature and perform a meta-analysis of HRQOL changes caused by sustained virologic response (SVR). MATERIAL AND METHODS: The PubMed was searched using the keywords Hepatitis C, Quality of Life and Therapy. The reviewers came to a consensus on articles that were selected to full reading and those that should be included in the study and a meta-analysis was performed of mean change difference between responders and non-responders. RESULTS: Eleven studies were included in the systematic review and four in the metaanalysis. Of these, nine studies showed more favorable outcome for responders, and they had a better outcome even in studies that evaluated only cirrhotic patients, previous non-responders, relapsers, patients in first treatment and patients unaware of treatment response. Moreover, the meta-analysis showed that the general health and vitality domains had statistically significant mean change difference between responders and non-responders, presenting a summary effect of 6.3 (CI 95% 2.5-10.0) and 7.8 (CI 95% 3.4- 12.1) respectively. CONCLUSION: There is evidence indicating that SVR is accompanied by an improvement in HRQOL and patients reaching SVR have clinically relevant improvement in domains of general health and vitality.
INTRODUCTION: It is known that patients with chronic hepatitis C have a lower health-related quality of life (HRQOL) than the general population and evidence suggests that the hepatitis C virus (HCV) could exert direct neuropathic action on HRQOL. From this perspective, the virus clearance should be accompanied by improvement in HRQOL. Thus, we sought to review systematically the evidence in the literature and perform a meta-analysis of HRQOL changes caused by sustained virologic response (SVR). MATERIAL AND METHODS: The PubMed was searched using the keywords Hepatitis C, Quality of Life and Therapy. The reviewers came to a consensus on articles that were selected to full reading and those that should be included in the study and a meta-analysis was performed of mean change difference between responders and non-responders. RESULTS: Eleven studies were included in the systematic review and four in the metaanalysis. Of these, nine studies showed more favorable outcome for responders, and they had a better outcome even in studies that evaluated only cirrhotic patients, previous non-responders, relapsers, patients in first treatment and patients unaware of treatment response. Moreover, the meta-analysis showed that the general health and vitality domains had statistically significant mean change difference between responders and non-responders, presenting a summary effect of 6.3 (CI 95% 2.5-10.0) and 7.8 (CI 95% 3.4- 12.1) respectively. CONCLUSION: There is evidence indicating that SVR is accompanied by an improvement in HRQOL and patients reaching SVR have clinically relevant improvement in domains of general health and vitality.
Authors: Joseph A Boscarino; Mei Lu; Anne C Moorman; Stuart C Gordon; Loralee B Rupp; Philip R Spradling; Eyasu H Teshale; Mark A Schmidt; Vinutha Vijayadeva; Scott D Holmberg Journal: Hepatology Date: 2015-01-30 Impact factor: 17.425
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Authors: Benjamin P Linas; Devra M Barter; Jared A Leff; Madeline DiLorenzo; Bruce R Schackman; Charles R Horsburgh; Sabrina A Assoumou; Joshua A Salomon; Milton C Weinstein; Arthur Y Kim; Kenneth A Freedberg Journal: AIDS Date: 2014-01-28 Impact factor: 4.632
Authors: Glória O Orge; Thais R Dellavechia; José Abraão Carneiro-Neto; Lucas Araújo-de-Freitas; Carla H C Daltro; Carlos T Santos; Lucas C Quarantini Journal: PLoS One Date: 2015-05-27 Impact factor: 3.240
Authors: Benjamin P Linas; Devra M Barter; Jared A Leff; Sabrina A Assoumou; Joshua A Salomon; Milton C Weinstein; Arthur Y Kim; Bruce R Schackman Journal: PLoS One Date: 2014-05-19 Impact factor: 3.752
Authors: Mychelle Morais-de-Jesus; Renato Daltro-Oliveira; Karine Miranda Pettersen; Adriana Dantas-Duarte; Luciana Di-Domizio Amaral; Patrícia Cavalcanti-Ribeiro; Carlos Teles Santos; Maria Isabel Schinoni; Liana R Netto; Lucas Araújo-de-Freitas; Raymundo Paraná; Angela Miranda-Scippa; Karestan C Koenen; Lucas C Quarantini Journal: PLoS One Date: 2014-10-23 Impact factor: 3.240
Authors: María-Carlota Londoño; Mar Riveiro-Barciela; Adriana Ahumada; Raquel Muñoz-Gómez; Mercé Roget; María J Devesa-Medina; Miguel Ángel Serra; Carmen A Navascués; Carme Baliellas; Teresa Aldamiz-Echevarría; María L Gutiérrez; Benjamín Polo-Lorduy; Isabel Carmona; Salvador Benlloch; Lucía Bonet; Javier García-Samaniego; Miguel Jiménez-Pérez; Senador Morán-Sánchez; Ángeles Castro; Manuel Delgado; Francisco Gea-Rodríguez; Ignacio Martín-Granizo; María Luisa Montes; Luís Morano; Manuel A Castaño; Ignacio de Los Santos; Montserrat Laguno; Juan Emilio Losa; Marta Montero-Alonso; Antonio Rivero; Cristina de Álvaro; Amanda Manzanares; Josep Mallolas; Guillermina Barril; Emilio González-Parra; Luisa García-Buey Journal: PLoS One Date: 2019-09-24 Impact factor: 3.240
Authors: Ricardo Henrique-Araújo; Lucas C Quarantini; André C Caribé; Felipe C Argolo; Ana Paula Jesus-Nunes; Mychelle Morais-de-Jesus; Adriana Dantas-Duarte; Tayne Miranda Moreira; Irismar Reis de Oliveira Journal: Braz J Infect Dis Date: 2019-07-22 Impact factor: 3.257