INTRODUCTION: Passive smoke is carcinogenic but its association with head and neck squamous cell carcinoma (HNSCC) is uncertain. METHODS: We conducted a case-control study of childhood passive smoke exposure (CPSE) and HNSCC in 858 cases and 806 frequency-matched controls using an interviewer-administered questionnaire. Odds ratios (OR) and 95% confidence intervals (CI) were estimated with logistic regression controlling for adult smoking in the total study population, and in never-smokers only (184 cases and 415 controls). CPSE was also studied in oropharyngeal separately from other HNSCC using polytomous logistic regression. RESULTS: CPSE was associated with HNSCC (OR, 1.28; 95% CI, 1.01-1.63) after controlling for adult smoking and other factors. This association was similar in magnitude, although not statistically significant, among subjects who never smoked as adults (OR, 1.19, 95% CI, 0.80-1.76). CPSE was associated more strongly with oropharyngeal cancer (a HNSCC subtype commonly associated with human papillomavirus (HPV) infection) than with HNSCC at non-oropharyngeal sites (OR, 2.02; 95% CI, 1.01-4.06, N=52 cases vs. OR, 1.04; 95% CI, 0.68-1.60, N=132 cases; P-for-heterogeneity=0.08). CONCLUSIONS: Data from this large US-based case control study suggest a role for CPSE in HNSCC etiology.
INTRODUCTION: Passive smoke is carcinogenic but its association with head and neck squamous cell carcinoma (HNSCC) is uncertain. METHODS: We conducted a case-control study of childhood passive smoke exposure (CPSE) and HNSCC in 858 cases and 806 frequency-matched controls using an interviewer-administered questionnaire. Odds ratios (OR) and 95% confidence intervals (CI) were estimated with logistic regression controlling for adult smoking in the total study population, and in never-smokers only (184 cases and 415 controls). CPSE was also studied in oropharyngeal separately from other HNSCC using polytomous logistic regression. RESULTS: CPSE was associated with HNSCC (OR, 1.28; 95% CI, 1.01-1.63) after controlling for adult smoking and other factors. This association was similar in magnitude, although not statistically significant, among subjects who never smoked as adults (OR, 1.19, 95% CI, 0.80-1.76). CPSE was associated more strongly with oropharyngeal cancer (a HNSCC subtype commonly associated with humanpapillomavirus (HPV) infection) than with HNSCC at non-oropharyngeal sites (OR, 2.02; 95% CI, 1.01-4.06, N=52 cases vs. OR, 1.04; 95% CI, 0.68-1.60, N=132 cases; P-for-heterogeneity=0.08). CONCLUSIONS: Data from this large US-based case control study suggest a role for CPSE in HNSCC etiology.
Authors: Z F Zhang; H Morgenstern; M R Spitz; D P Tashkin; G P Yu; T C Hsu; S P Schantz Journal: Cancer Epidemiol Biomarkers Prev Date: 2000-10 Impact factor: 4.254
Authors: Marjut A M Rintala; Seija E Grénman; Marja E Järvenkylä; Kari J Syrjänen; Stina M Syrjänen Journal: Clin Infect Dis Date: 2005-11-07 Impact factor: 9.079
Authors: P Vineis; L Airoldi; F Veglia; L Olgiati; R Pastorelli; H Autrup; A Dunning; S Garte; E Gormally; P Hainaut; C Malaveille; G Matullo; M Peluso; K Overvad; A Tjonneland; F Clavel-Chapelon; H Boeing; V Krogh; D Palli; S Panico; R Tumino; B Bueno-De-Mesquita; P Peeters; G Berglund; G Hallmans; R Saracci; E Riboli Journal: BMJ Date: 2005-01-28
Authors: K F Summersgill; E M Smith; B T Levy; J M Allen; T H Haugen; L P Turek Journal: Oral Surg Oral Med Oral Pathol Oral Radiol Endod Date: 2001-01
Authors: Mostafa Qorbani; Ramin Heshmat; Mohammad Reza Hashemi-Aghdam; Gita Shafiee; Mehdi Ebrahimi; Hanieh-Sadat Ejtahed; Mehdi Yaseri; Mohammad Esmaeil Motlagh; Roya Kelishadi Journal: BMC Public Health Date: 2022-03-29 Impact factor: 3.295