BACKGROUND: Brain injury in term neonatal hypoxic-ischemic encephalopathy (HIE) emerges on magnetic resonance imaging (MRI) by day 3. This study aimed to address the relationship of MRI, diffusion tensor imaging (DTI), and MR spectroscopic imaging (MRSI) findings on days 1 and 3 in a prospective cohort of term newborns with HIE. METHODS: A total of 24 term newborns with HIE were prospectively studied with MRI on days 1 and 3; 19 were imaged with DTI and MRSI on days 1 and 3. MRI was assessed using validated scores. The relationship between MRI, DTI, and MRSI values on days 1 and 3 was determined using linear regression for repeated measures. RESULTS: Conventional MRI showed a complex variation of findings from day 1 to 3. In gray matter, mean diffusivity (Dav) and metabolite ratios measured on day 1 were predictive of values on day 3 (all P ≤ 0.04). In white matter, Dav, fractional anisotropy (FA), and N-acetylaspartate (NAA)/choline on days 1 and 3 were strongly related (all P ≤ 0.003). Hypothermia appeared to attenuate the severity and progression of brain injury in the six treated newborns. CONCLUSION: In term newborns with HIE, quantitative MR values on days 1 and 3 are strongly associated, providing an objective measure of injury before qualitative images.
BACKGROUND:Brain injury in term neonatal hypoxic-ischemicencephalopathy (HIE) emerges on magnetic resonance imaging (MRI) by day 3. This study aimed to address the relationship of MRI, diffusion tensor imaging (DTI), and MR spectroscopic imaging (MRSI) findings on days 1 and 3 in a prospective cohort of term newborns with HIE. METHODS: A total of 24 term newborns with HIE were prospectively studied with MRI on days 1 and 3; 19 were imaged with DTI and MRSI on days 1 and 3. MRI was assessed using validated scores. The relationship between MRI, DTI, and MRSI values on days 1 and 3 was determined using linear regression for repeated measures. RESULTS: Conventional MRI showed a complex variation of findings from day 1 to 3. In gray matter, mean diffusivity (Dav) and metabolite ratios measured on day 1 were predictive of values on day 3 (all P ≤ 0.04). In white matter, Dav, fractional anisotropy (FA), and N-acetylaspartate (NAA)/choline on days 1 and 3 were strongly related (all P ≤ 0.003). Hypothermia appeared to attenuate the severity and progression of brain injury in the six treated newborns. CONCLUSION: In term newborns with HIE, quantitative MR values on days 1 and 3 are strongly associated, providing an objective measure of injury before qualitative images.
Authors: Christopher P Wayock; Rachel L Meserole; Suchi Saria; Jacky M Jennings; Thierry A G M Huisman; Frances J Northington; Ernest M Graham Journal: Am J Obstet Gynecol Date: 2014-03-18 Impact factor: 8.661
Authors: Anil N Shetty; Ashley M Lucke; Peiying Liu; Magdalena Sanz Cortes; Joseph L Hagan; Zili D Chu; Jill V Hunter; Hanzhang Lu; Wesley Lee; Jeffrey R Kaiser Journal: Pediatr Radiol Date: 2018-11-06
Authors: Shamik B Trivedi; Zachary A Vesoulis; Rakesh Rao; Steve M Liao; Joshua S Shimony; Robert C McKinstry; Amit M Mathur Journal: Pediatr Radiol Date: 2017-06-16
Authors: S Kwan; E Boudes; G Gilbert; C Saint-Martin; S Albrecht; M Shevell; P Wintermark Journal: AJNR Am J Neuroradiol Date: 2015-07-02 Impact factor: 3.825
Authors: Yangming Ou; Lilla Zöllei; Kallirroi Retzepi; Victor Castro; Sara V Bates; Steve Pieper; Katherine P Andriole; Shawn N Murphy; Randy L Gollub; Patricia Ellen Grant Journal: Hum Brain Mapp Date: 2017-03-31 Impact factor: 5.038
Authors: Jessica L Wisnowski; Pia Wintermark; Sonia L Bonifacio; Christopher D Smyser; A James Barkovich; A David Edwards; Linda S de Vries; Terrie E Inder; Vann Chau Journal: Semin Fetal Neonatal Med Date: 2021-10-29 Impact factor: 3.726