Literature DB >> 23618281

Investigation of water-soluble inclusion complex of hypericin with β-cyclodextrin polymer.

Wang Zhang1, Xiangdong Gong, Yin Cai, Chuanli Zhang, Xing Yu, Jian Fan, Guowang Diao.   

Abstract

A water-soluble inclusion complex of hypericin (HY) with β-cyclodextrin polymer (CDP) was achieved by supramolecular interactions between HY and CDP. The inclusion complex (HY-CDP) was characterized by (1)H NMR, FTIR, and UV-vis spectroscopies. Compared with HY, the water-solubility of HY-CDP was greatly enhanced because of the water-soluble CDP host. The mole ratio of β-cyclodextrin (β-CD) unit in CDP to HY was determined as 2:1. At 25 °C, the dissociated constant of HY-CDP was measured as 1.47×10(-7) mol L(-1) by UV-vis spectroscopy. In the formation of inclusion complexes, CDP could overcome the β-CD drawbacks - such as the poor water-solubility and the restriction of single cavity size, indicating it was able to use as a universal solubilizer for pharmaceutical application.
Copyright © 2013 Elsevier Ltd. All rights reserved.

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Year:  2013        PMID： 23618281     DOI： 10.1016/j.carbpol.2013.03.020

Source DB:  PubMed          Journal:  Carbohydr Polym        ISSN： 0144-8617            Impact factor:   9.381


  9 in total

1.  Thermoresponsive Liposomes for Photo-Triggered Release of Hypericin Cyclodextrin Inclusion Complex for Efficient Antimicrobial Photodynamic Therapy.

Authors:  Alice Abu Dayyih; Bernd Gutberlet; Eduard Preis; Konrad H Engelhardt; Muhammad Umair Amin; Ahmed M Abdelsalam; Martina Bonsu; Udo Bakowsky
Journal:  ACS Appl Mater Interfaces       Date:  2022-07-05       Impact factor: 10.383

2.  Study to Probe Subsistence of Host-Guest Inclusion Complexes of α and β-Cyclodextrins with Biologically Potent Drugs for Safety Regulatory Dischargement.

Authors:  Biplab Rajbanshi; Subhadeep Saha; Koyeli Das; Biraj Kumar Barman; Swarnab Sengupta; Arindam Bhattacharjee; Mahendra Nath Roy
Journal:  Sci Rep       Date:  2018-08-29       Impact factor: 4.379

3.  Improvement of Skin Penetration, Antipollutant Activity and Skin Hydration of 7,3',4'-Trihydroxyisoflavone Cyclodextrin Inclusion Complex.

Authors:  Pao Hsien Huang; Stephen Chu Sung Hu; Feng Lin Yen; Chih Hua Tseng
Journal:  Pharmaceutics       Date:  2019-08-08       Impact factor: 6.321

4.  Thermo/pH dual-responsive micelles based on the host-guest interaction between benzimidazole-terminated graft copolymer and β-cyclodextrin-functionalized star block copolymer for smart drug delivery.

Authors:  Floria Adeli; Farhang Abbasi; Mirzaagha Babazadeh; Soodabeh Davaran
Journal:  J Nanobiotechnology       Date:  2022-02-22       Impact factor: 10.435

5.  Synthesis and Characterization of an Inclusion Complex of dl-Aminoglutethimide with β-Cyclodextrin and Its Innovative Application in a Biological System: Computational and Experimental Investigations.

Authors:  Samapika Ray; Niloy Roy; Biraj Kumar Barman; Paramita Karmakar; Pranish Bomzan; Biplab Rajbanshi; Vikas Kumar Dakua; Ankita Dutta; Anoop Kumar; Mahendra Nath Roy
Journal:  ACS Omega       Date:  2022-03-28

6.  Investigation of the Drug Carrier Properties of Insoluble Cyclodextrin Polymer Microspheres.

Authors:  Ádám Haimhoffer; Alexandra Vas; Gabriella Árvai; Éva Fenyvesi; László Jicsinszky; István Budai; Attila Bényei; Géza Regdon; Ágnes Rusznyák; Gábor Vasvári; Judit Váradi; Ildikó Bácskay; Miklós Vecsernyés; Ferenc Fenyvesi
Journal:  Biomolecules       Date:  2022-07-02

7.  A water-soluble inclusion complex of pedunculoside with the polymer β-cyclodextrin: a novel anti-inflammation agent with low toxicity.

Authors:  Chang Liu; Wang Zhang; Hao Yang; Weidong Sun; Xiangdong Gong; Junxian Zhao; Yun Sun; Guowang Diao
Journal:  PLoS One       Date:  2014-07-11       Impact factor: 3.240

8.  Antioxidant MMCC ameliorates catch-up growth related metabolic dysfunction.

Authors:  Liping Ju; Wenxin Tong; Miaoyan Qiu; Weili Shen; Jichao Sun; Sheng Zheng; Ying Chen; Wentao Liu; Jingyan Tian
Journal:  Oncotarget       Date:  2017-10-23

9.  Characterization of Curcumin/Cyclodextrin Polymer Inclusion Complex and Investigation on Its Antioxidant and Antiproliferative Activities.

Authors:  Jianping Chen; Xiaoming Qin; Saiyi Zhong; Suhua Chen; Weiming Su; Ying Liu
Journal:  Molecules       Date:  2018-05-15       Impact factor: 4.411
  9 in total

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