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Literature DB >> 23616733

Recent new drug approvals, part 2: drugs undergoing active clinical studies in children.

Rebecca F Chhim¹, Chasity M Shelton, Michael L Christensen.

Abstract

The objective of this 2-part review is to provide information about drugs that have been recently approved by the US Food and Drug Administration. Part 1 reviewed recently approved drugs with pediatric indications. Part 2 reviews drugs recently approved only in adults and have published or ongoing studies in children.

Entities: Species

Keywords: Food and Drug Administration; drug approval; drug industry; pediatrics

Year: 2013 PMID： 23616733 PMCID： PMC3626063 DOI： 10.5863/1551-6776-18.1.14

Source DB: PubMed Journal: J Pediatr Pharmacol Ther ISSN： 1551-6776

47 in total

1. The safety, tolerability, and efficacy of a liquid formulation of deferiprone in young children with transfusional iron overload.

Authors: Moshen S ElAlfy; Moshen El Alfy; Teny Tjitra Sari; Chan Lee Lee; Fernando Tricta; Amal El-Beshlawy
Journal: J Pediatr Hematol Oncol Date: 2010-11 Impact factor: 1.289

Review 2. Recent advances in management and treatment of hereditary angioedema.

Authors: Niti Sardana; Timothy J Craig
Journal: Pediatrics Date: 2011-11-07 Impact factor: 7.124

3. Efficacy and safety of roflumilast in the treatment of asthma.

Authors: Eric D Bateman; Jose Luis Izquierdo; Ulf Harnest; Peter Hofbauer; Pal Magyar; Christine Schmid-Wirlitsch; Stefan Leichtl; Dirk Bredenbröker
Journal: Ann Allergy Asthma Immunol Date: 2006-05 Impact factor: 6.347

Review 4. Hereditary angioedema in childhood: an approach to management.

Authors: Didier G Ebo; Marjoke M Verweij; Kathleen J De Knop; Margo M Hagendorens; Chris H Bridts; Luc S De Clerck; Wim J Stevens
Journal: Paediatr Drugs Date: 2010-08-01 Impact factor: 3.022

5. Clostridium difficile infection in hospitalized children in the United States.

Authors: Cade M Nylund; Anthony Goudie; Jose M Garza; Gerry Fairbrother; Mitchell B Cohen
Journal: Arch Pediatr Adolesc Med Date: 2011-01-03

6. Survival in BRAF V600-mutant advanced melanoma treated with vemurafenib.

Authors: Jeffrey A Sosman; Kevin B Kim; Lynn Schuchter; Rene Gonzalez; Anna C Pavlick; Jeffrey S Weber; Grant A McArthur; Thomas E Hutson; Stergios J Moschos; Keith T Flaherty; Peter Hersey; Richard Kefford; Donald Lawrence; Igor Puzanov; Karl D Lewis; Ravi K Amaravadi; Bartosz Chmielowski; H Jeffrey Lawrence; Yu Shyr; Fei Ye; Jiang Li; Keith B Nolop; Richard J Lee; Andrew K Joe; Antoni Ribas
Journal: N Engl J Med Date: 2012-02-23 Impact factor: 91.245

2. Efficacy and safety of combined oral iron chelation therapy with deferasirox and deferiprone in a patient with beta-thalassemia major and persistent iron overload.

Authors: Samin Alavi; Elham Sadeghi; Azin Ashenagar
Journal: Blood Res Date: 2014-03-24

2 in total

Recent new drug approvals, part 2: drugs undergoing active clinical studies in children.

1. The safety, tolerability, and efficacy of a liquid formulation of deferiprone in young children with transfusional iron overload.

Review 2. Recent advances in management and treatment of hereditary angioedema.

3. Efficacy and safety of roflumilast in the treatment of asthma.

Review 4. Hereditary angioedema in childhood: an approach to management.

5. Clostridium difficile infection in hospitalized children in the United States.

6. Survival in BRAF V600-mutant advanced melanoma treated with vemurafenib.

7. Reduction in sputum neutrophil and eosinophil numbers by the PDE4 inhibitor roflumilast in patients with COPD.

8. Dramatic increase in venous thromboembolism in children's hospitals in the United States from 2001 to 2007.

Review 9. Medullary thyroid cancer: molecular biology and novel molecular therapies.

Review 10. Anti-CTLA4 monoclonal antibodies: the past and the future in clinical application.

1. Diagnosis and management of cerebral venous sinus thrombosis in children: a single-center retrospective analysis.

2. Efficacy and safety of combined oral iron chelation therapy with deferasirox and deferiprone in a patient with beta-thalassemia major and persistent iron overload.