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Literature DB >> 23616664

Foamy virus Gag p71-p68 cleavage is required for template switch of the reverse transcriptase.

Ralf Spannaus¹, Anna Schneider, Maximilian J Hartl, Birgitta M Wöhrl, Jochen Bodem.

Abstract

In contrast to orthoretroviruses, processing of foamy viral p71 Gag is limited to a single cleavage site. Nevertheless, Gag maturation is essential for infectivity, but deletion of p3 results in a modest drop in infectivity. Here, we show that Gag processing of p71 to p68 and p3 is essential for full-length cDNA synthesis, while inactivation of Gag cleavage results in cDNAs containing only the RU5 region; cDNAs encompassing the U3 region were almost undetectable.

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Year: 2013 PMID： 23616664 PMCID： PMC3700290 DOI： 10.1128/JVI.00833-13

Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103

12 in total

1. Primate foamy virus Pol proteins are imported into the nucleus.

Authors: Horst Imrich; Martin Heinkelein; Ottmar Herchenröder; Axel Rethwilm
Journal: J Gen Virol Date: 2000-12 Impact factor: 3.891

2. Carboxy-terminal cleavage of the human foamy virus Gag precursor molecule is an essential step in the viral life cycle.

Authors: J Enssle; N Fischer; A Moebes; B Mauer; U Smola; A Rethwilm
Journal: J Virol Date: 1997-10 Impact factor: 5.103

3. Regulation of foamy virus protease activity by viral RNA: a novel and unique mechanism among retroviruses.

Authors: Maximilian J Hartl; Jochen Bodem; Fabian Jochheim; Axel Rethwilm; Paul Rösch; Birgitta M Wöhrl
Journal: J Virol Date: 2011-02-16 Impact factor: 5.103

4. Prototype foamy virus protease activity is essential for intraparticle reverse transcription initiation but not absolutely required for uncoating upon host cell entry.

Authors: Sylvia Hütter; Erik Müllers; Nicole Stanke; Juliane Reh; Dirk Lindemann
Journal: J Virol Date: 2013-01-02 Impact factor: 5.103

5. Proteolytic activity, the carboxy terminus of Gag, and the primer binding site are not required for Pol incorporation into foamy virus particles.

Authors: D N Baldwin; M L Linial
Journal: J Virol Date: 1999-08 Impact factor: 5.103

6. Improved primate foamy virus vectors and packaging constructs.

Authors: Martin Heinkelein; Marco Dressler; Gergely Jármy; Matthias Rammling; Horst Imrich; Jana Thurow; Dirk Lindemann; Axel Rethwilm
Journal: J Virol Date: 2002-04 Impact factor: 5.103

7. Active foamy virus proteinase is essential for virus infectivity but not for formation of a Pol polyprotein.

Authors: J Konvalinka; M Löchelt; H Zentgraf; R M Flügel; H G Kräusslich
Journal: J Virol Date: 1995-11 Impact factor: 5.103

8. Analysis of prototype foamy virus particle-host cell interaction with autofluorescent retroviral particles.

Authors: Kristin Stirnnagel; Daniel Lüftenegger; Annett Stange; Anka Swiersy; Erik Müllers; Juliane Reh; Nicole Stanke; Arend Grosse; Salvatore Chiantia; Heiko Keller; Petra Schwille; Helmut Hanenberg; Hanswalter Zentgraf; Dirk Lindemann
Journal: Retrovirology Date: 2010-05-17 Impact factor: 4.602

Foamy virus Gag p71-p68 cleavage is required for template switch of the reverse transcriptase.

1. Primate foamy virus Pol proteins are imported into the nucleus.

2. Carboxy-terminal cleavage of the human foamy virus Gag precursor molecule is an essential step in the viral life cycle.

3. Regulation of foamy virus protease activity by viral RNA: a novel and unique mechanism among retroviruses.

4. Prototype foamy virus protease activity is essential for intraparticle reverse transcription initiation but not absolutely required for uncoating upon host cell entry.

5. Proteolytic activity, the carboxy terminus of Gag, and the primer binding site are not required for Pol incorporation into foamy virus particles.

6. Improved primate foamy virus vectors and packaging constructs.

7. Active foamy virus proteinase is essential for virus infectivity but not for formation of a Pol polyprotein.

8. Analysis of prototype foamy virus particle-host cell interaction with autofluorescent retroviral particles.

9. The prototype foamy virus protease is active independently of the integrase domain.

10. AZT resistance of simian foamy virus reverse transcriptase is based on the excision of AZTMP in the presence of ATP.

Review 1. Foamy Virus Protein-Nucleic Acid Interactions during Particle Morphogenesis.

Review 2. Structural and Functional Aspects of Foamy Virus Protease-Reverse Transcriptase.