PURPOSE: To assess the validity of the diagnostic codes of congenital malformations (CMs) recorded in two of Québec's administrative databases. METHODS: A cohort of pregnancies and infants born to asthmatic and non-asthmatic women in 1990-2002 was reconstructed using Québec's administrative databases. From this cohort, we selected 269 infants with a CM and 144 without CM born to asthmatic women, together with 284 and 138 infants, respectively, born to non-asthmatic women. The diagnoses of CMs recorded in the databases were compared with the diagnoses written by the physicians in the infants' medical charts. The positive predictive values (PPV) and negative predictive values (NPV) for all, major, and several specific CMs were estimated. RESULTS: The PPVs for all CMs and major CMs were 82.2% (95% confidence interval (CI): 78.5%-85.9%) and 78.1% (74.1%-82.1%), respectively, in the asthmatic group and were 79.2% (75.4%-83.1%) and 69.0% (64.6%-73.4%), respectively, in the non-asthmatic group. PPVs >80% were found for several specific CMs, including cardiac, cleft, and limb CMs in both groups. The NPV for any CM was 88.2% (95% CI: 85.1%-91.3%) in the asthmatic group and 94.2% (92.2%-96.2%) in the non-asthmatic group. CONCLUSIONS: Québec's administrative databases are valid tools for epidemiological research of CMs. The results were similar between infants born to women with and without asthma.
PURPOSE: To assess the validity of the diagnostic codes of congenital malformations (CMs) recorded in two of Québec's administrative databases. METHODS: A cohort of pregnancies and infants born to asthmatic and non-asthmatic women in 1990-2002 was reconstructed using Québec's administrative databases. From this cohort, we selected 269 infants with a CM and 144 without CM born to asthmatic women, together with 284 and 138 infants, respectively, born to non-asthmatic women. The diagnoses of CMs recorded in the databases were compared with the diagnoses written by the physicians in the infants' medical charts. The positive predictive values (PPV) and negative predictive values (NPV) for all, major, and several specific CMs were estimated. RESULTS: The PPVs for all CMs and major CMs were 82.2% (95% confidence interval (CI): 78.5%-85.9%) and 78.1% (74.1%-82.1%), respectively, in the asthmatic group and were 79.2% (75.4%-83.1%) and 69.0% (64.6%-73.4%), respectively, in the non-asthmatic group. PPVs >80% were found for several specific CMs, including cardiac, cleft, and limb CMs in both groups. The NPV for any CM was 88.2% (95% CI: 85.1%-91.3%) in the asthmatic group and 94.2% (92.2%-96.2%) in the non-asthmatic group. CONCLUSIONS: Québec's administrative databases are valid tools for epidemiological research of CMs. The results were similar between infants born to women with and without asthma.
Authors: Anick Bérard; Padma Kaul; Sherif Eltonsy; Brandace Winquist; Dan Chateau; Steven Hawken; Ann Sprague; Mark Walker; Sasha Bernatsky; Michal Abrahamowicz; Cristiano Soares de Moura; Évelyne Vinet; Bruce Carleton; Gillian Hanley; Tim Oberlander; Odile Sheehy; Yessica Haydee Gomez; Jessica Gorgui; Anamaria Savu Journal: PLoS One Date: 2022-09-20 Impact factor: 3.752
Authors: Susan E Andrade; Anick Bérard; Hedvig M E Nordeng; Mollie E Wood; Marleen M H J van Gelder; Sengwee Toh Journal: Curr Epidemiol Rep Date: 2017-04-18
Authors: Joan K Morris; Ester Garne; Maria Loane; Ingeborg Barisic; James Densem; Anna Latos-Bieleńska; Amanda Neville; Anna Pierini; Judith Rankin; Anke Rissmann; Hermien de Walle; Joachim Tan; Joanne Emma Given; Hugh Claridge Journal: BMJ Open Date: 2021-06-28 Impact factor: 2.692