OBJECTIVES: We and others showed that migraineurs are at increased risk of subclinical and clinical ischemic brain lesions. Migraineurs also have a higher prevalence of frequent syncope and orthostatic intolerance, symptoms that are associated with transient reductions in cerebral blood flow. In this study, we assessed whether these autonomic symptoms may contribute to the increased risk of brain lesions in migraine. METHODS:Migraineurs (n = 291) and controls (n = 140) from the population-based, cross-sectional CAMERA (Cerebral Abnormalities in Migraine, an Epidemiologic Risk Analysis) cohort (aged 30-60 years, and free of other neurologic symptoms) underwent 1) brain MRI scan, and 2) structured telephone interview including questions on frequent syncope (≥5/lifetime) and orthostatic intolerance. RESULTS:Frequent syncope (odds ratio [OR] = 2.7; 95% confidence interval: 1.3-5.5) and orthostatic intolerance (OR = 2.0 [1.1-3.6]) were independent risk factors for high load of deep white matter lesions. Effects were strongest in women and similar in migraineurs and controls. Migraine diagnosis did not mediate or moderate these associations. Individuals with orthostatic intolerance had higher prevalence of high periventricular white matter lesion load (OR = 1.9 [1.1-3.5]). Syncope and orthostatic intolerance were not related to subclinical infarcts or infratentorial lesions. CONCLUSIONS:Frequent syncope, orthostatic intolerance, and migraine independently increase the risk of white matter lesions, particularly in females.
RCT Entities:
OBJECTIVES: We and others showed that migraineurs are at increased risk of subclinical and clinical ischemic brain lesions. Migraineurs also have a higher prevalence of frequent syncope and orthostatic intolerance, symptoms that are associated with transient reductions in cerebral blood flow. In this study, we assessed whether these autonomic symptoms may contribute to the increased risk of brain lesions in migraine. METHODS:Migraineurs (n = 291) and controls (n = 140) from the population-based, cross-sectional CAMERA (Cerebral Abnormalities in Migraine, an Epidemiologic Risk Analysis) cohort (aged 30-60 years, and free of other neurologic symptoms) underwent 1) brain MRI scan, and 2) structured telephone interview including questions on frequent syncope (≥5/lifetime) and orthostatic intolerance. RESULTS: Frequent syncope (odds ratio [OR] = 2.7; 95% confidence interval: 1.3-5.5) and orthostatic intolerance (OR = 2.0 [1.1-3.6]) were independent risk factors for high load of deep white matter lesions. Effects were strongest in women and similar in migraineurs and controls. Migraine diagnosis did not mediate or moderate these associations. Individuals with orthostatic intolerance had higher prevalence of high periventricular white matter lesion load (OR = 1.9 [1.1-3.5]). Syncope and orthostatic intolerance were not related to subclinical infarcts or infratentorial lesions. CONCLUSIONS: Frequent syncope, orthostatic intolerance, and migraine independently increase the risk of white matter lesions, particularly in females.
Authors: F E de Leeuw; J C de Groot; M Oudkerk; J C Witteman; A Hofman; J van Gijn; M M Breteler Journal: Ann Neurol Date: 1999-12 Impact factor: 10.422
Authors: F E de Leeuw; J C de Groot; E Achten; M Oudkerk; L M Ramos; R Heijboer; A Hofman; J Jolles; J van Gijn; M M Breteler Journal: J Neurol Neurosurg Psychiatry Date: 2001-01 Impact factor: 10.154
Authors: Inge H Palm-Meinders; Hille Koppen; Gisela M Terwindt; Lenore J Launer; Junya Konishi; Juliette M E Moonen; Jacobus T N Bakkers; Paul A M Hofman; Baldur van Lew; Huub A M Middelkoop; Mark A van Buchem; Michel D Ferrari; Mark C Kruit Journal: JAMA Date: 2012-11-14 Impact factor: 56.272
Authors: Mark C Kruit; Mark A van Buchem; Paul A M Hofman; Jacobus T N Bakkers; Gisela M Terwindt; Michel D Ferrari; Lenore J Launer Journal: JAMA Date: 2004-01-28 Impact factor: 56.272
Authors: Roland D Thijs; Michele Brignole; Cristian Falup-Pecurariu; Alessandra Fanciulli; Roy Freeman; Pietro Guaraldi; Jens Jordan; Mario Habek; Max Hilz; Anne Pavy-Le Traon; Iva Stankovic; Walter Struhal; Richard Sutton; Gregor Wenning; J Gert Van Dijk Journal: Clin Auton Res Date: 2021-03-19 Impact factor: 4.435
Authors: Shorena Janelidze; Daniel Lindqvist; Veronica Francardo; Sara Hall; Henrik Zetterberg; Kaj Blennow; Charles H Adler; Thomas G Beach; Geidy E Serrano; Danielle van Westen; Elisabet Londos; M Angela Cenci; Oskar Hansson Journal: Neurology Date: 2015-10-28 Impact factor: 9.910
Authors: Willebrordus Pj van Oosterhout; Guus G Schoonman; Dirk P Saal; Roland D Thijs; Michel D Ferrari; J Gert van Dijk Journal: Cephalalgia Date: 2019-10-09 Impact factor: 6.292