Literature DB >> 23616

gamma-Radiolyses of DNA in oxygenated aqueous solution. Structure of an alkali-labile site.

M Dizdaroglu, D Schulte-Frohlinde, C von Sonntag.   

Abstract

Erythritol-1-d1 has been isolated from gamma-irradiated aqueous oxygenated solution of DNA after reductions with NaBD4, alkali and phosphatase treatment. It is concluded that this product stems from a D-erythrose 2,4-diphosphate unit in the DNA which is formed via a sequence of reactions following H-abstraction at C-2' by OH radicals.

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Year:  1977        PMID： 23616     DOI： 10.1515/znc-1977-11-1226

Source DB:  PubMed          Journal:  Z Naturforsch C Biosci        ISSN： 0341-0382


  4 in total

1.  Quantification of the 2-deoxyribonolactone and nucleoside 5'-aldehyde products of 2-deoxyribose oxidation in DNA and cells by isotope-dilution gas chromatography mass spectrometry: differential effects of gamma-radiation and Fe2+-EDTA.

Authors:  Wan Chan; Bingzi Chen; Lianrong Wang; Koli Taghizadeh; Michael S Demott; Peter C Dedon
Journal:  J Am Chem Soc       Date:  2010-05-05       Impact factor: 15.419

2.  Model of the interactions of calichemicin gamma 1 with a DNA fragment from pBR322.

Authors:  R C Hawley; L L Kiessling; S L Schreiber
Journal:  Proc Natl Acad Sci U S A       Date:  1989-02       Impact factor: 11.205

Review 3.  Radiation damage to phi X174 DNA and biological effects.

Authors:  M V Lafleur; H Loman
Journal:  Radiat Environ Biophys       Date:  1986       Impact factor: 1.925

4.  Effect of quadruplex conformation on radiation-induced formation of 8-hydroxyguanine and unaltered base release in polyguanylic acid.

Authors:  D Grygoryev; J D Zimbrick
Journal:  Radiat Res       Date:  2010-01       Impact factor: 2.841
  4 in total

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