PURPOSE OF REVIEW: Many surface antigens have been previously used to identify hematopoietic stem cells or cellular elements of the hematopoietic niche. However, to date, not a single surface marker has been identified as a common marker expressed on murine and human hematopoietic stem cells and on cells of the hematopoietic niche. Recently, a few laboratories, including ours, recognized the importance of CD166 as a functional marker on both stem cells and osteoblasts and have begun to characterize the role of CD166 in hematopoiesis. RECENT FINDINGS: Expression of CD166 on hematopoietic cells and cells in the marrow microenvironment was first reported more than a decade ago. Lately, however, a more prominent role for CD166 in normal hematopoiesis and in cancer biology including metastasis began to emerge. This review will cover the significance of CD166 in identifying normal hematopoietic stem cells and cells of the hematopoietic niche and highlight how CD166-mediated homophilic interactions between both cell types may be critical for stem cell function. SUMMARY: The conserved homology between murine and human CD166 and its involvement in metastasis provides an excellent bridge for translational investigations aimed at enhancing stem cell engraftment and clinical utility of stem cells and at using CD166 as a therapeutic target in cancer.
PURPOSE OF REVIEW: Many surface antigens have been previously used to identify hematopoietic stem cells or cellular elements of the hematopoietic niche. However, to date, not a single surface marker has been identified as a common marker expressed on murine and human hematopoietic stem cells and on cells of the hematopoietic niche. Recently, a few laboratories, including ours, recognized the importance of CD166 as a functional marker on both stem cells and osteoblasts and have begun to characterize the role of CD166 in hematopoiesis. RECENT FINDINGS: Expression of CD166 on hematopoietic cells and cells in the marrow microenvironment was first reported more than a decade ago. Lately, however, a more prominent role for CD166 in normal hematopoiesis and in cancer biology including metastasis began to emerge. This review will cover the significance of CD166 in identifying normal hematopoietic stem cells and cells of the hematopoietic niche and highlight how CD166-mediated homophilic interactions between both cell types may be critical for stem cell function. SUMMARY: The conserved homology between murine and humanCD166 and its involvement in metastasis provides an excellent bridge for translational investigations aimed at enhancing stem cell engraftment and clinical utility of stem cells and at using CD166 as a therapeutic target in cancer.
Authors: Linlin Xu; Khalid S Mohammad; Hao Wu; Colin Crean; Bradley Poteat; Yinghua Cheng; Angelo A Cardoso; Christophe Machal; Helmut Hanenberg; Rafat Abonour; Melissa A Kacena; John Chirgwin; Attaya Suvannasankha; Edward F Srour Journal: Cancer Res Date: 2016-09-07 Impact factor: 12.701
Authors: Jing Zhang; Joydeep Ghosh; Safa F Mohamad; Chi Zhang; Xinxin Huang; Maegan L Capitano; Andrea M Gunawan; Scott Cooper; Bin Guo; Qingchun Cai; Hal E Broxmeyer; Edward F Srour Journal: Stem Cells Date: 2019-08-14 Impact factor: 5.845
Authors: Paul E Chappell; Lee I Garner; Jun Yan; Clive Metcalfe; Deborah Hatherley; Steven Johnson; Carol V Robinson; Susan M Lea; Marion H Brown Journal: Structure Date: 2015-07-02 Impact factor: 5.006
Authors: R A Hooker; B R Chitteti; P H Egan; Y H Cheng; E R Himes; T Meijome; E F Srour; R K Fuchs; M A Kacena Journal: J Musculoskelet Neuronal Interact Date: 2015-03 Impact factor: 2.041