Literature DB >> 23614954

The class III phosphatidylinositol 3-kinase PIK3C3/VPS34 regulates endocytosis and autophagosome-autolysosome formation in podocytes.

Wibke Bechtel1, Martin Helmstädter, Jan Balica, Björn Hartleben, Christoph Schell, Tobias B Huber.   

Abstract

Phosphatidylinositol phosphates are key regulators of vesicle identity, formation and trafficking. In mammalian cells, the evolutionarily conserved class III PtdIns 3-kinase PIK3C3/VPS34 is part of a large multiprotein complex that catalyzes the localized phosphorylation of phosphatidylinositol to phosphatidylinositol-3-phosphate (PtdIns3P). We demonstrate that PIK3C3 has a key function in vesicular trafficking, endocytosis and autophagosome-autolysosome formation in the highly specialized glomerular podocytes.

Entities:  

Keywords:  Pik3c3; Vps34; autophago-lysosomal formation; autophagy; endocytosis; glomerulosclerosis; phosphoinositide 3-kinase; podocyte; proteinuria

Mesh：

Substances：

Year:  2013        PMID： 23614954      PMCID： PMC3722319          DOI： 10.4161/auto.24634

Source DB:  PubMed          Journal:  Autophagy        ISSN： 1554-8627            Impact factor:   16.016


  10 in total

1.  Class III PI3K Biology.

Authors:  Manuella Caux; Gaetan Chicanne; Sonia Severin
Journal:  Curr Top Microbiol Immunol       Date:  2022       Impact factor: 4.737

2.  A dual role for the class III PI3K, Vps34, in platelet production and thrombus growth.

Authors:  Colin Valet; Marie Levade; Gaëtan Chicanne; Benoit Bilanges; Cendrine Cabou; Julien Viaud; Marie-Pierre Gratacap; Frédérique Gaits-Iacovoni; Bart Vanhaesebroeck; Bernard Payrastre; Sonia Severin
Journal:  Blood       Date:  2017-09-13       Impact factor: 22.113

3.  Beclin 1, an Essential Component and Master Regulator of PI3K-III in Health and Disease.

Authors:  Nicole C McKnight; Yue Zhenyu
Journal:  Curr Pathobiol Rep       Date:  2013-12-01

4.  Class III PI3K Vps34 Controls Thyroid Hormone Production by Regulating Thyroglobulin Iodination, Lysosomal Proteolysis, and Tissue Homeostasis.

Authors:  Giuseppina Grieco; Tongsong Wang; Ophélie Delcorte; Catherine Spourquet; Virginie Janssens; Aurélie Strickaert; Héloïse P Gaide Chevronnay; Xiao-Hui Liao; Benoît Bilanges; Samuel Refetoff; Bart Vanhaesebroeck; Carine Maenhaut; Pierre J Courtoy; Christophe E Pierreux
Journal:  Thyroid       Date:  2019-12-02       Impact factor: 6.568

5.  Pik3c3 deficiency in myeloid cells imparts partial resistance to experimental autoimmune encephalomyelitis associated with reduced IL-1β production.

Authors:  Guan Yang; Wenqiang Song; Jielin Xu; J Luke Postoak; Feixiong Cheng; Jennifer Martinez; Jianhua Zhang; Lan Wu; Luc Van Kaer
Journal:  Cell Mol Immunol       Date:  2020-11-24       Impact factor: 22.096

6.  Vps34/PI3KC3 deletion in kidney proximal tubules impairs apical trafficking and blocks autophagic flux, causing a Fanconi-like syndrome and renal insufficiency.

Authors:  Giuseppina Grieco; Virginie Janssens; Héloïse P Gaide Chevronnay; Francisca N'Kuli; Patrick Van Der Smissen; Tongsong Wang; Jingdong Shan; Seppo Vainio; Benoit Bilanges; François Jouret; Bart Vanhaesebroeck; Christophe E Pierreux; Pierre J Courtoy
Journal:  Sci Rep       Date:  2018-09-20       Impact factor: 4.379

7.  Aurone derivatives as Vps34 inhibitors that modulate autophagy.

Authors:  Guodong Li; Joshua William Boyle; Chung-Nga Ko; Wu Zeng; Vincent Kam Wai Wong; Jian-Bo Wan; Philip Wai Hong Chan; Dik-Lung Ma; Chung-Hang Leung
Journal:  Acta Pharm Sin B       Date:  2019-01-30       Impact factor: 11.413

8.  The class 3 PI3K coordinates autophagy and mitochondrial lipid catabolism by controlling nuclear receptor PPARα.

Authors:  Anton Iershov; Ivan Nemazanyy; Chantal Alkhoury; Muriel Girard; Esther Barth; Nicolas Cagnard; Alexandra Montagner; Dominique Chretien; Elena I Rugarli; Herve Guillou; Mario Pende; Ganna Panasyuk
Journal:  Nat Commun       Date:  2019-04-05       Impact factor: 14.919

9.  Autophagy protein NRBF2 has reduced expression in Alzheimer's brains and modulates memory and amyloid-beta homeostasis in mice.

Authors:  Véronik Lachance; Qian Wang; Eric Sweet; Insup Choi; Cui-Zan Cai; Xu-Xu Zhuang; Yuanxi Zhang; Jessica Li Jiang; Robert D Blitzer; Ozlem Bozdagi-Gunal; Bin Zhang; Jia-Hong Lu; Zhenyu Yue
Journal:  Mol Neurodegener       Date:  2019-11-27       Impact factor: 14.195

10.  Regulation of mammalian autophagy by class II and III PI 3-kinases through PI3P synthesis.

Authors:  Kelly Devereaux; Claudia Dall'Armi; Abel Alcazar-Roman; Yuta Ogasawara; Xiang Zhou; Fan Wang; Akitsugu Yamamoto; Pietro De Camilli; Gilbert Di Paolo
Journal:  PLoS One       Date:  2013-10-03       Impact factor: 3.240
  10 in total

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