BACKGROUND: Transforming growth factor-β1 (TGF-β1) exerts broad anti-inflammatory and immunosuppressive effects and plays a key role in self-tolerance. Complete knockout of TGF-β1 in mice results in autoimmunity and multi-organ inflammatory syndrome. The aim of the present study was to determine TGF-β1 serum levels in healthy individuals and in patients with typical systemic or organ-specific autoimmune disorders such as systemic lupus erythematosus (SLE) and Hashimoto's thyroiditis (HT) in an attempt to elucidate the importance of TGF-β1 in human autoimmunity. PATIENTS AND METHODS: Serum concentrations of TGF-β1 were determined using an enzyme-linked immunosorbent assay in a group of 53 patients with SLE (87% women) and 123 with HT (95% women). Results were compared with those from 66 healthy controls (HC; 80% women). RESULTS: Significantly lower levels of serum TGF-β1 were found in patients with SLE and HT than those found in HC (mean ± SD: SLE: 8.7 ± 2.5 ng/mL; HT: 18.74 ± 8.2 ng/mL; HC: 33.01 ± 2.4.8 ng/mL; SLE versus HC: p<0.001; HT versus HC: p<0.001). Also, serum levels of TGF-β1 were significantly lower in patients with SLE compared to patients with HT (p<0.001). The serum levels TGF-β1 were significantly higher in men than in women in the HC group (63.4 ± 28.1 ng/mL versus 26.6 ± 17.5 ng/mL, P<0.001), but were similar for men and women in both patients groups (p>0.05). CONCLUSIONS: Our data demonstrate that altered TGF-β1 levels are associated with the presence of autoimmune disorders, and that TGF-β1 concentrations seem to be more profoundly depressed in systemic autoimmune diseases than in autoimmune thyroid disorders. Autoimmunity may have been triggered as a result of a decreased immunosuppressive effect induced by depressed TGF-β1 levels in patients with SLE and Hashimoto's thyroiditis.
BACKGROUND: Transforming growth factor-β1 (TGF-β1) exerts broad anti-inflammatory and immunosuppressive effects and plays a key role in self-tolerance. Complete knockout of TGF-β1 in mice results in autoimmunity and multi-organ inflammatory syndrome. The aim of the present study was to determine TGF-β1 serum levels in healthy individuals and in patients with typical systemic or organ-specific autoimmune disorders such as systemic lupus erythematosus (SLE) and Hashimoto's thyroiditis (HT) in an attempt to elucidate the importance of TGF-β1 in humanautoimmunity. PATIENTS AND METHODS: Serum concentrations of TGF-β1 were determined using an enzyme-linked immunosorbent assay in a group of 53 patients with SLE (87% women) and 123 with HT (95% women). Results were compared with those from 66 healthy controls (HC; 80% women). RESULTS: Significantly lower levels of serum TGF-β1 were found in patients with SLE and HT than those found in HC (mean ± SD: SLE: 8.7 ± 2.5 ng/mL; HT: 18.74 ± 8.2 ng/mL; HC: 33.01 ± 2.4.8 ng/mL; SLE versus HC: p<0.001; HT versus HC: p<0.001). Also, serum levels of TGF-β1 were significantly lower in patients with SLE compared to patients with HT (p<0.001). The serum levels TGF-β1 were significantly higher in men than in women in the HC group (63.4 ± 28.1 ng/mL versus 26.6 ± 17.5 ng/mL, P<0.001), but were similar for men and women in both patients groups (p>0.05). CONCLUSIONS: Our data demonstrate that altered TGF-β1 levels are associated with the presence of autoimmune disorders, and that TGF-β1 concentrations seem to be more profoundly depressed in systemic autoimmune diseases than in autoimmune thyroid disorders. Autoimmunity may have been triggered as a result of a decreased immunosuppressive effect induced by depressed TGF-β1 levels in patients with SLE and Hashimoto's thyroiditis.
Authors: Yi Zhou; Huimei Chen; Li Liu; Xueqing Yu; Galina K Sukhova; Min Yang; Lijun Zhang; Vasileios C Kyttaris; George C Tsokos; Isaac E Stillman; Takaharu Ichimura; Joseph V Bonventre; Peter Libby; Guo-Ping Shi Journal: J Immunol Date: 2017-02-20 Impact factor: 5.422
Authors: Caroline H Wallace; Bill X Wu; Mohammad Salem; Ephraim A Ansa-Addo; Alessandra Metelli; Shaoli Sun; Gary Gilkeson; Mark J Shlomchik; Bei Liu; Zihai Li Journal: JCI Insight Date: 2018-04-05