Literature DB >> 2361469

Effects of parathyroid hormone and calcitonin on alkaline phosphatase activity and matrix calcification in rabbit growth-plate chondrocyte cultures.

Y Kato1, A Shimazu, K Nakashima, F Suzuki, A Jikko, M Iwamoto.   

Abstract

The effects of PTH and calcitonin (CT) on the expression of mineralization-related phenotypes by chondrocytes were examined. In cultures of pelleted growth-plate chondrocytes. PTH caused 60-90% decreases in alkaline phosphatase activity, the incorporation of 45Ca into insoluble material, and the calcium content during the post-mitotic stage. These effects of PTH were dose-dependent and reversible. In contrast, CT increased alkaline phosphatase activity, 45Ca incorporation into insoluble material, and the calcium content by 1.4- to 1.8-fold. These observations suggest that PTH directly inhibits the expression of the mineralization-related phenotypes by growth-plate chondrocytes, and that CT has the opposite effects.

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Year:  1990        PMID： 2361469     DOI： 10.1210/endo-127-1-114

Source DB:  PubMed          Journal:  Endocrinology        ISSN： 0013-7227            Impact factor:   4.736


  13 in total

1.  A rapid and ultrasensitive method for measurement of DNA, calcium and protein content, and alkaline phosphatase activity of chondrocyte cultures.

Authors:  C C Teixeira; M Hatori; P S Leboy; M Pacifici; I M Shapiro
Journal:  Calcif Tissue Int       Date:  1995-03       Impact factor: 4.333

2.  Role of 1,25-dihydroxycholecalciferol in growth-plate cartilage: inhibition of terminal differentiation of chondrocytes in vitro and in vivo.

Authors:  Y Kato; A Shimazu; M Iwamoto; K Nakashima; T Koike; F Suzuki; Y Nishii; K Sato
Journal:  Proc Natl Acad Sci U S A       Date:  1990-09       Impact factor: 11.205

3.  Parathyroid hormone and transforming growth factor-beta1 coregulate chondrocyte differentiation in vitro.

Authors:  E Nasatzky; E Azran; D D Dean; B D Boyan; Z Schwartz
Journal:  Endocrine       Date:  2000-12       Impact factor: 3.633

4.  Articular cartilage endurance and resistance to osteoarthritic changes require transcription factor Erg.

Authors:  Yoichi Ohta; Takahiro Okabe; Colleen Larmour; Agnese Di Rocco; Marijke W Maijenburg; Amanda Phillips; Nancy A Speck; Shigeyuki Wakitani; Takashi Nakamura; Yoshihiko Yamada; Motomi Enomoto-Iwamoto; Maurizio Pacifici; Masahiro Iwamoto
Journal:  Arthritis Rheumatol       Date:  2015-10       Impact factor: 10.995

5.  Retinoic acid modulation of glutathione and cysteine metabolism in chondrocytes.

Authors:  C C Teixeira; I M Shapiro; M Hatori; R Rajpurohit; C Koch
Journal:  Biochem J       Date:  1996-02-15       Impact factor: 3.857

6.  Effects of interleukin-1 on syntheses of alkaline phosphatase, type X collagen, and 1,25-dihydroxyvitamin D3 receptor, and matrix calcification in rabbit chondrocyte cultures.

Authors:  Y Kato; K Nakashima; M Iwamoto; H Murakami; H Hiranuma; T Koike; F Suzuki; H Fuchihata; Y Ikehara; M Noshiro
Journal:  J Clin Invest       Date:  1993-11       Impact factor: 14.808

7.  Phosphodiesterase activity is a novel property of alkaline phosphatase from osseous plate.

Authors:  A A Rezende; J M Pizauro; P Ciancaglini; F A Leone
Journal:  Biochem J       Date:  1994-07-15       Impact factor: 3.857

8.  Expression of parathyroid hormone-related protein in rat articular cartilage.

Authors:  T Tsukazaki; A Ohtsuru; H Enomoto; H Yano; K Motomura; M Ito; H Namba; K Iwasaki; S Yamashita
Journal:  Calcif Tissue Int       Date:  1995-09       Impact factor: 4.333

Review 9.  Slipped capital femoral epiphysis associated with hyperparathyroidism. A case report.

Authors:  J Kinoshita; K Kaneda; T Matsuno; Y Hosokawa; R Nagashio
Journal:  Int Orthop       Date:  1995       Impact factor: 3.075

10.  Two biochemical indices of mouse bone formation are increased, in vivo, in response to calcitonin.

Authors:  J R Farley; S L Hall; S Herring; N M Tarbaux
Journal:  Calcif Tissue Int       Date:  1992-01       Impact factor: 4.333
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