Literature DB >> 23612989

Development and function of cortical thymic epithelial cells.

Kensuke Takada1, Izumi Ohigashi, Michiyuki Kasai, Hiroshi Nakase, Yousuke Takahama.   

Abstract

The thymic cortex provides a microenvironment that supports the generation and T cell antigen receptor (TCR)-mediated selection of CD4(+)CD8(+)TCRαβ(+) thymocytes. Cortical thymic epithelial cells (cTECs) are the essential component that forms the architecture of the thymic cortex and induces the generation as well as the selection of newly generated T cells. Here we summarize current knowledge on the development, function, and heterogeneity of cTECs, focusing on the expression and function of β5t, a cTEC-specific subunit of the thymoproteasome.

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Year:  2014        PMID： 23612989     DOI： 10.1007/82_2013_322

Source DB:  PubMed          Journal:  Curr Top Microbiol Immunol        ISSN： 0070-217X            Impact factor:   4.291


  9 in total

1.  Bioengineering Thymus Organoids to Restore Thymic Function and Induce Donor-Specific Immune Tolerance to Allografts.

Authors:  Yong Fan; Asako Tajima; Saik Kia Goh; Xuehui Geng; Giulio Gualtierotti; Maria Grupillo; Antonina Coppola; Suzanne Bertera; William A Rudert; Ipsita Banerjee; Rita Bottino; Massimo Trucco
Journal:  Mol Ther       Date:  2015-04-23       Impact factor: 11.454

2.  Prolongevity hormone FGF21 protects against immune senescence by delaying age-related thymic involution.

Authors:  Yun-Hee Youm; Tamas L Horvath; David J Mangelsdorf; Steven A Kliewer; Vishwa Deep Dixit
Journal:  Proc Natl Acad Sci U S A       Date:  2016-01-11       Impact factor: 11.205

3.  MTOR signaling is essential for the development of thymic epithelial cells and the induction of central immune tolerance.

Authors:  Zhanfeng Liang; Lianjun Zhang; Huiting Su; Rong Luan; Ning Na; Lina Sun; Yang Zhao; Xiaodong Zhang; Qian Zhang; Juan Li; Lianfeng Zhang; Yong Zhao
Journal:  Autophagy       Date:  2018-01-29       Impact factor: 16.016

Review 4.  Generation of diversity in thymic epithelial cells.

Authors:  Yousuke Takahama; Izumi Ohigashi; Song Baik; Graham Anderson
Journal:  Nat Rev Immunol       Date:  2017-03-20       Impact factor: 53.106

5.  Inhibins tune the thymocyte selection process by regulating thymic stromal cell differentiation.

Authors:  Ebzadrel Carbajal-Franco; Marisol de la Fuente-Granada; Germán R Alemán-Muench; Eduardo A García-Zepeda; Gloria Soldevila
Journal:  J Immunol Res       Date:  2015-04-20       Impact factor: 4.818

6.  LTβR controls thymic portal endothelial cells for haematopoietic progenitor cell homing and T-cell regeneration.

Authors:  Yaoyao Shi; Weiwei Wu; Qian Chai; Qingqing Li; Yu Hou; Huan Xia; Boyang Ren; Hairong Xu; Xiaohuan Guo; Caiwei Jin; Mengjie Lv; Zhongnan Wang; Yang-Xin Fu; Mingzhao Zhu
Journal:  Nat Commun       Date:  2016-08-05       Impact factor: 14.919

7.  Failures in thymus medulla regeneration during immune recovery cause tolerance loss and prime recipients for auto-GVHD.

Authors:  Abdullah S Alawam; Emilie J Cosway; Kieran D James; Beth Lucas; Andrea Bacon; Sonia M Parnell; Andrea J White; William E Jenkinson; Graham Anderson
Journal:  J Exp Med       Date:  2021-12-15       Impact factor: 14.307

Review 8.  The Thymic Orchestration Involving Aire, miRNAs, and Cell-Cell Interactions during the Induction of Central Tolerance.

Authors:  Geraldo Aleixo Passos; Daniella Arêas Mendes-da-Cruz; Ernna Hérida Oliveira
Journal:  Front Immunol       Date:  2015-07-14       Impact factor: 7.561

9.  From pre-DP, post-DP, SP4, and SP8 Thymocyte Cell Counts to a Dynamical Model of Cortical and Medullary Selection.

Authors:  Maria Sawicka; Gretta L Stritesky; Joseph Reynolds; Niloufar Abourashchi; Grant Lythe; Carmen Molina-París; Kristin A Hogquist
Journal:  Front Immunol       Date:  2014-02-14       Impact factor: 7.561
  9 in total

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