AIM: The present study attempts to understand the role of methylenetetrahydrofolate reductase C677T (MTHFR C677T) in recurrent pregnancy losses in North Indian women because of hyperhomocysteinemia in light of serum folate and vitamin B₁₂. METHODS: One hundred and seven women with three or more consecutive unexplained recurrent pregnancy losses and 343 women with two or more successful and uncomplicated pregnancies were recruited. Plasma homocysteine, serum folate and vitamin B₁₂ were analyzed using chemiluminescence. MTHFR C677T detection was completed in all subjects. RESULTS: MTHFR genotypic distribution among cases and controls showed no significant difference (P=0.409). However, MTHFR C677T polymorphism was found to be significantly associated with increased homocysteine in the case group (P=0.031). Hyperhomocysteinemia and vitamin B₁₂ deficiency were found to be significant risk factors for recurrent pregnancy loss (RPL) (OR=7.02 and 16.39, respectively). Folate deficiency was more common in controls (63.47%) as compared to the case group (2.56%). CONCLUSION: Low vitamin B₁₂ increases homocysteine, specifically among T allele carrying case mothers, suggesting T allele is detrimental with B₁₂ deficiency. The study emphasizes the importance of vitamin B₁₂ in the prevention of RPL in North Indian women.
AIM: The present study attempts to understand the role of methylenetetrahydrofolate reductase C677T (MTHFRC677T) in recurrent pregnancy losses in North Indian women because of hyperhomocysteinemia in light of serum folate and vitamin B₁₂. METHODS: One hundred and seven women with three or more consecutive unexplained recurrent pregnancy losses and 343 women with two or more successful and uncomplicated pregnancies were recruited. Plasma homocysteine, serum folate and vitamin B₁₂ were analyzed using chemiluminescence. MTHFRC677T detection was completed in all subjects. RESULTS:MTHFR genotypic distribution among cases and controls showed no significant difference (P=0.409). However, MTHFRC677T polymorphism was found to be significantly associated with increased homocysteine in the case group (P=0.031). Hyperhomocysteinemia and vitamin B₁₂ deficiency were found to be significant risk factors for recurrent pregnancy loss (RPL) (OR=7.02 and 16.39, respectively). Folate deficiency was more common in controls (63.47%) as compared to the case group (2.56%). CONCLUSION: Low vitamin B₁₂ increases homocysteine, specifically among T allele carrying case mothers, suggesting T allele is detrimental with B₁₂ deficiency. The study emphasizes the importance of vitamin B₁₂ in the prevention of RPL in North Indian women.
Authors: Krishnamachari Srinivasan; Tinku Thomas; Aruna Rose Mary Kapanee; Asha Ramthal; David C Bellinger; Ronald J Bosch; Anura V Kurpad; Christopher Duggan Journal: Matern Child Nutr Date: 2016-06-29 Impact factor: 3.092
Authors: Melanie Horita; Carolina Tosin Bueno; Andrea R Horimoto; Pedro A Lemos; Antonio A Morandini-Filho; Jose E Krieger; Paulo C J L Santos; Alexandre C Pereira Journal: Int J Cardiol Heart Vasc Date: 2016-11-24
Authors: Eun Sun Kim; Jung Oh Kim; Hui Jeong An; Jung Hyun Sakong; Hyun Ah Lee; Ji Hyang Kim; Eun Hee Ahn; Young Ran Kim; Woo Sik Lee; Nam Keun Kim Journal: Clin Exp Reprod Med Date: 2017-09-26
Authors: Siwei Chen; Wedad Alhassen; Ryan Yoshimura; Angele De Silva; Geoffrey W Abbott; Pierre Baldi; Amal Alachkar Journal: Commun Biol Date: 2020-07-30