Literature DB >> 23612203

Ex vivo responses of Plasmodium falciparum clinical isolates to conventional and new antimalarial drugs in Niger.

Mariama Issaka1, Adamou Salissou, Ibrahim Arzika, Julia Guillebaud, Abani Maazou, Sabine Specht, Halima Zamanka, Thierry Fandeur.   

Abstract

Little is known about resistance of Plasmodium falciparum to antimalarials in Sahelian countries. Here we investigated the drug susceptibilities of fresh isolates collected in Niger post-deployment of artemisinin-based combination therapies (ACTs). We found that the parasites remained highly susceptible to new (dihydroartemisinin, lumefantrine, pyronaridine, and piperaquine) and conventional (amodiaquine and chloroquine) antimalarial drugs. The introduction of ACTs in 2005 and their further deployment nationwide have therefore not resulted in a decrease in P. falciparum susceptibilities to these antimalarials.

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Year:  2013        PMID： 23612203      PMCID： PMC3697322          DOI： 10.1128/AAC.02383-12

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  30 in total

1.  Efficacy of chloroquine in the treatment of uncomplicated, Plasmodium falciparum malaria in Niamey, Niger, in 2001.

Authors:  F Dugelay; E Adehossi; S Adamou; I Ousmane; D Parzy; J Delmont; P Parola
Journal:  Ann Trop Med Parasitol       Date:  2003-01

2.  Mutations in the P. falciparum digestive vacuole transmembrane protein PfCRT and evidence for their role in chloroquine resistance.

Authors:  D A Fidock; T Nomura; A K Talley; R A Cooper; S M Dzekunov; M T Ferdig; L M Ursos; A B Sidhu; B Naudé; K W Deitsch; X Z Su; J C Wootton; P D Roepe; T E Wellems
Journal:  Mol Cell       Date:  2000-10       Impact factor: 17.970

Review 3.  Artemisinin-based combination therapies: a vital tool in efforts to eliminate malaria.

Authors:  Richard T Eastman; David A Fidock
Journal:  Nat Rev Microbiol       Date:  2009-11-02       Impact factor: 60.633

4.  Field-based evidence for the linkage of pfcrt and pfdhfr drug-resistant malaria genotypes and clinical profiles of severe malaria in Niger.

Authors:  Maman Laminou Ibrahim; Françoise Gay-Andrieu; Eric Adehossi; Veronique Lacroix; Milijaona Randrianarivelojosia; Jean-Bernard Duchemin
Journal:  Microbes Infect       Date:  2007-02-20       Impact factor: 2.700

5.  [Chloroquine sensitivity of Plasmodium falciparum at the Gamkalley Clinic and the Nigerian armed forces PMI (Niamey, Niger)].

Authors:  P Parola; I Ali; F Djermakoye; N Crassard; C Bendavid; B Faugère; P Condomines
Journal:  Bull Soc Pathol Exot       Date:  1999-12

6.  In vitro activities of piperaquine, lumefantrine, and dihydroartemisinin in Kenyan Plasmodium falciparum isolates and polymorphisms in pfcrt and pfmdr1.

Authors:  Leah Mwai; Steven M Kiara; Abdi Abdirahman; Lewa Pole; Anja Rippert; Abdi Diriye; Pete Bull; Kevin Marsh; Steffen Borrmann; Alexis Nzila
Journal:  Antimicrob Agents Chemother       Date:  2009-09-21       Impact factor: 5.191

7.  Selection of parasites with diminished drug susceptibility by amodiaquine-containing antimalarial regimens in Uganda.

Authors:  Fatima Nawaz; Samuel L Nsobya; Moses Kiggundu; Moses Joloba; Philip J Rosenthal
Journal:  J Infect Dis       Date:  2009-12-01       Impact factor: 5.226

Review 8.  Artemisinin-based combination treatment of falciparum malaria.

Authors:  François Nosten; Nicholas J White
Journal:  Am J Trop Med Hyg       Date:  2007-12       Impact factor: 2.345

9.  Artemisinin resistance in Plasmodium falciparum malaria.

Authors:  Arjen M Dondorp; François Nosten; Poravuth Yi; Debashish Das; Aung Phae Phyo; Joel Tarning; Khin Maung Lwin; Frederic Ariey; Warunee Hanpithakpong; Sue J Lee; Pascal Ringwald; Kamolrat Silamut; Mallika Imwong; Kesinee Chotivanich; Pharath Lim; Trent Herdman; Sen Sam An; Shunmay Yeung; Pratap Singhasivanon; Nicholas P J Day; Niklas Lindegardh; Duong Socheat; Nicholas J White
Journal:  N Engl J Med       Date:  2009-07-30       Impact factor: 91.245

10.  In vitro activities of piperaquine and other 4-aminoquinolines against clinical isolates of Plasmodium falciparum in Cameroon.

Authors:  Leonardo K Basco; Pascal Ringwald
Journal:  Antimicrob Agents Chemother       Date:  2003-04       Impact factor: 5.191
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  7 in total

1.  Influence of the pfmdr1 Gene on In Vitro Sensitivities of Piperaquine in Thai Isolates of Plasmodium falciparum.

Authors:  Mathirut Mungthin; Ekularn Watanatanasup; Naruemon Sitthichot; Nantana Suwandittakul; Rommanee Khositnithikul; Stephen A Ward
Journal:  Am J Trop Med Hyg       Date:  2017-04-06       Impact factor: 2.345

2.  Impact of antimalarial treatment and chemoprevention on the drug sensitivity of malaria parasites isolated from ugandan children.

Authors:  Patrick Tumwebaze; Melissa D Conrad; Andrew Walakira; Norbert LeClair; Oswald Byaruhanga; Christine Nakazibwe; Benjamin Kozak; Jessica Bloome; Jaffer Okiring; Abel Kakuru; Victor Bigira; James Kapisi; Jennifer Legac; Jiri Gut; Roland A Cooper; Moses R Kamya; Diane V Havlir; Grant Dorsey; Bryan Greenhouse; Samuel L Nsobya; Philip J Rosenthal
Journal:  Antimicrob Agents Chemother       Date:  2015-03-09       Impact factor: 5.191

3.  Diverse mutational pathways converge on saturable chloroquine transport via the malaria parasite's chloroquine resistance transporter.

Authors:  Robert L Summers; Anurag Dave; Tegan J Dolstra; Sebastiano Bellanca; Rosa V Marchetti; Megan N Nash; Sashika N Richards; Valerie Goh; Robyn L Schenk; Wilfred D Stein; Kiaran Kirk; Cecilia P Sanchez; Michael Lanzer; Rowena E Martin
Journal:  Proc Natl Acad Sci U S A       Date:  2014-04-11       Impact factor: 11.205

4.  Multinormal in vitro distribution of Plasmodium falciparum susceptibility to piperaquine and pyronaridine.

Authors:  Aurélie Pascual; Marilyn Madamet; Sébastien Briolant; Tiphaine Gaillard; Rémy Amalvict; Nicolas Benoit; Dominique Travers; Bruno Pradines
Journal:  Malar J       Date:  2015-02-05       Impact factor: 2.979

5.  Epidemiology of malaria in an area of seasonal transmission in Niger and implications for the design of a seasonal malaria chemoprevention strategy.

Authors:  Julia Guillebaud; Aboubacar Mahamadou; Halima Zamanka; Mariama Katzelma; Ibrahim Arzika; Maman L Ibrahim; Elfatih Ab Eltahir; Rabiou Labbo; Pierre Druilhe; Jean-Bernard Duchemin; Thierry Fandeur
Journal:  Malar J       Date:  2013-10-30       Impact factor: 2.979

6.  Low Prevalence of Pfcrt Resistance Alleles among Patients with Uncomplicated Falciparum Malaria in Niger Six Years after Chloroquine Withdrawal.

Authors:  Adamou Salissou; Halima Zamanka; Brigitte Biyghe Binze; Taiana Rivière; Magalie Tichit; Maman Laminou Ibrahim; Thierry Fandeur
Journal:  Malar Res Treat       Date:  2014-11-23

7.  Drying anti-malarial drugs in vitro tests to outsource SYBR green assays.

Authors:  Karim Traore; Adeline Lavoignat; Guillaume Bonnot; Fatimata Sow; Giuliana C Bess; Marjorie Chavant; Frederick Gay; Ogobara Doumbo; Stephane Picot
Journal:  Malar J       Date:  2015-02-21       Impact factor: 2.979
  7 in total

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