Literature DB >> 2361011

Rhodopsin activation causes retinal degeneration in Drosophila rdgC mutant.

F Steele1, J E O'Tousa.   

Abstract

Drosophila rdgC (retinal degeneration-C) mutants show normal retinal morphology and photoreceptor physiology at young ages. Dark-reared rdgC flies retain this wild-type phenotype, but light-reared mutants undergo retinal degeneration. rdgC photoreceptors with low levels of rhodopsin as a result of vitamin A deprivation or a mutant rhodopsin (ninaE) gene fail to show rdgC-induced degeneration even after prolonged light treatment, demonstrating that degeneration occurs as a result of light stimulation of rhodopsin. Analysis of norpA; rdgC flies shows that the norpA-encoded phospholipase C, the target enzyme of the G protein activated by rhodopsin, is not required for rdgC-induced degeneration. Thus the rdgC+ gene product is required to prevent retinal degeneration that results from a previously unrecognized consequence of rhodopsin stimulation.

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Year:  1990        PMID： 2361011     DOI： 10.1016/0896-6273(90)90141-2

Source DB:  PubMed          Journal:  Neuron        ISSN： 0896-6273            Impact factor:   17.173


  24 in total

1.  Normal light response, photoreceptor integrity, and rhodopsin dephosphorylation in mice lacking both protein phosphatases with EF hands (PPEF-1 and PPEF-2).

Authors:  P Ramulu; M Kennedy; W H Xiong; J Williams; M Cowan; D Blesh; K W Yau; J B Hurley; J Nathans
Journal:  Mol Cell Biol       Date:  2001-12       Impact factor: 4.272

2.  Identification and characterization of a conserved family of protein serine/threonine phosphatases homologous to Drosophila retinal degeneration C.

Authors:  P M Sherman; H Sun; J P Macke; J Williams; P M Smallwood; J Nathans
Journal:  Proc Natl Acad Sci U S A       Date:  1997-10-14       Impact factor: 11.205

3.  The Phosphorylation State of the Drosophila TRP Channel Modulates the Frequency Response to Oscillating Light In Vivo.

Authors:  Olaf Voolstra; Elisheva Rhodes-Mordov; Ben Katz; Jonas-Peter Bartels; Claudia Oberegelsbacher; Susanne Katharina Schotthöfer; Bushra Yasin; Hanan Tzadok; Armin Huber; Baruch Minke
Journal:  J Neurosci       Date:  2017-03-17       Impact factor: 6.167

4.  rdgE: a novel retinal degeneration mutation in Drosophila melanogaster.

Authors:  T Zars; D R Hyde
Journal:  Genetics       Date:  1996-09       Impact factor: 4.562

5.  Light-dependent phosphorylation of the drosophila transient receptor potential ion channel.

Authors:  Olaf Voolstra; Katherina Beck; Claudia Oberegelsbacher; Jens Pfannstiel; Armin Huber
Journal:  J Biol Chem       Date:  2010-03-09       Impact factor: 5.157

6.  Constitutive activation of phototransduction by K296E opsin is not a cause of photoreceptor degeneration.

Authors:  T Li; W K Franson; J W Gordon; E L Berson; T P Dryja
Journal:  Proc Natl Acad Sci U S A       Date:  1995-04-11       Impact factor: 11.205

7.  Regulatory arrestin cycle secures the fidelity and maintenance of the fly photoreceptor cell.

Authors:  T Byk; M Bar-Yaacov; Y N Doza; B Minke; Z Selinger
Journal:  Proc Natl Acad Sci U S A       Date:  1993-03-01       Impact factor: 11.205

8.  Activation of caspase-3 in the retina of transgenic rats with the rhodopsin mutation s334ter during photoreceptor degeneration.

Authors:  C Liu; Y Li; M Peng; A M Laties; R Wen
Journal:  J Neurosci       Date:  1999-06-15       Impact factor: 6.167

Review 9.  Phototransduction and retinal degeneration in Drosophila.

Authors:  Tao Wang; Craig Montell
Journal:  Pflugers Arch       Date:  2007-05-09       Impact factor: 3.657

10.  The Drosophila tissue polarity gene inturned functions prior to wing hair morphogenesis in the regulation of hair polarity and number.

Authors:  P N Adler; J Charlton; W J Park
Journal:  Genetics       Date:  1994-07       Impact factor: 4.562
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