M Nuri Deniz1, E Erhan, G Ugur. 1. Department of Anaesthesiology and Reanimation, Ege University School of Medicine, Izmir, Turkey. mnurideniz@hotmail.com
Abstract
BACKGROUND:Intrathecal (IT) morphine provides prolonged analgesia after major surgery. AIM: The aim of our study was to assess the impact of intrathecal morphine 200 µg on patient-controlled analgesia (PCA) tramadol consumptions and postoperative pain in patients who underwent radical retropubic prostatectomy (RRP) under general anesthesia. MATERIALS AND METHODS: In this prospective trial, 56 men who underwentradical retropubic prostatectomy (RRP) were randomized into 2 groups. Group M received intrathecal morphine (200 µg) before the induction of general anesthesia. Group C did not receive intrathecal morphine. Postoperative analgesia was provided with tramadol PCA. Pain scores, tramadol consumption, adverse effects, rescue analgesia were recorded. RESULTS:Total tramadol consumption at 24 hours and pain scores during 12 hours postoperatively were significantly lower in Group M compared with Group C (p < 0.05). Rescue analgesia and postoperative nausea were lower in Group M than in Group C (p < 0.05). CONCLUSIONS:Intrathecal morphine 200 µg provided a significant reduction in tramadol consumption, postoperative pain scores, rescue analgesia, and postoperative nausea after RRP without serious adverse effects.
RCT Entities:
BACKGROUND: Intrathecal (IT) morphine provides prolonged analgesia after major surgery. AIM: The aim of our study was to assess the impact of intrathecal morphine 200 µg on patient-controlled analgesia (PCA) tramadol consumptions and postoperative pain in patients who underwent radical retropubic prostatectomy (RRP) under general anesthesia. MATERIALS AND METHODS: In this prospective trial, 56 men who underwent radical retropubic prostatectomy (RRP) were randomized into 2 groups. Group M received intrathecal morphine (200 µg) before the induction of general anesthesia. Group C did not receive intrathecal morphine. Postoperative analgesia was provided with tramadol PCA. Pain scores, tramadol consumption, adverse effects, rescue analgesia were recorded. RESULTS: Total tramadol consumption at 24 hours and pain scores during 12 hours postoperatively were significantly lower in Group M compared with Group C (p < 0.05). Rescue analgesia and postoperative nausea were lower in Group M than in Group C (p < 0.05). CONCLUSIONS: Intrathecal morphine 200 µg provided a significant reduction in tramadol consumption, postoperative pain scores, rescue analgesia, and postoperative nausea after RRP without serious adverse effects.
Authors: Christian M Beilstein; Markus Huber; Marc A Furrer; Lukas M Löffel; Patrick Y Wuethrich; Dominique Engel Journal: Eur J Pain Date: 2022-08-21 Impact factor: 3.651