Synthesis of new 1,5-diphenyl-3-1H-1,2,4-triazoles substituted with H-, alkyl, or carboxyl groups at C-3.

Amidines obtained from benzamides and DMF- or DMA-dimethylacetal were cyclized with phenylhydrazines to 3H- or 3-methyltriazoles. 3-Ethyltriazoles were synthesized from diacylamides. Triazole-3-carboxylic acides were prepared starting from anilines. The compounds were assayed in the rat adjuvant induced arthritis model. Some compounds show significant anti-inflammatory activity.