Literature DB >> 23608245

The ethics of creating children with three genetic parents.

Françoise Baylis1.   

Abstract

This article on mitochondrial replacement technology briefly explains and defends the legitimacy of such terms as 'three-parent embryos', 'three-parent babies' and 'three-person IVF'. Next, it reviews select ethical objections to mitochondrial replacement technology that fall into four, sometimes overlapping, categories: (i) harms to egg providers; (ii) harms to potential offspring and future generations; (iii) harms to specific interest groups; and (iv) harms to society. Taken together, these ethical objections are cause for serious concern and yet the development and future use of mitochondrial replacement technology is likely inevitable.
Copyright © 2013 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.

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Year:  2013        PMID: 23608245     DOI: 10.1016/j.rbmo.2013.03.006

Source DB:  PubMed          Journal:  Reprod Biomed Online        ISSN: 1472-6483            Impact factor:   3.828


  28 in total

1.  Harnessing the stem cell potential: the path to prevent mitochondrial disease.

Authors:  Akemi J Tanaka; Mark V Sauer; Dieter Egli; Daniel H Kort
Journal:  Nat Med       Date:  2013-12       Impact factor: 53.440

2.  Attitudes of clinical geneticists and certified genetic counselors to genome editing and its clinical applications: A nation-wide questionnaire survey in Japan.

Authors:  Iku Taguchi; Takahiro Yamada; Rina Akaishi; Issei Imoto; Kenji Kurosawa; Kaname Nakatani; Fumio Nomura; Haruka Hamanoue; Maki Hyodo; Hiromi Murakami; Hiroshi Yoshihashi; Junko Yotsumoto; Shinji Kosugi
Journal:  J Hum Genet       Date:  2019-07-05       Impact factor: 3.172

3.  Is the World of ART Ready for a Ménage à Trois?

Authors:  Gautam N Allahbadia
Journal:  J Obstet Gynaecol India       Date:  2015-04

4.  Risks and benefits of human germline genome editing: An ethical analysis.

Authors:  Giovanni Rubeis; Florian Steger
Journal:  Asian Bioeth Rev       Date:  2018-07-16

5.  Genetic affinity and the right to 'three-parent IVF'.

Authors:  G Owen Schaefer; Markus K Labude
Journal:  J Assist Reprod Genet       Date:  2017-09-18       Impact factor: 3.412

Review 6.  Social and ethical issues in mitochondrial donation.

Authors:  Rebecca Dimond
Journal:  Br Med Bull       Date:  2015-09       Impact factor: 4.291

Review 7.  CRISPR/Cas9 and mitochondrial gene replacement therapy: promising techniques and ethical considerations.

Authors:  Sarah Fogleman; Casey Santana; Casey Bishop; Alyssa Miller; David G Capco
Journal:  Am J Stem Cells       Date:  2016-08-20

8.  Revising, Correcting, and Transferring Genes.

Authors:  Bryan Cwik
Journal:  Am J Bioeth       Date:  2020-08       Impact factor: 11.229

9.  Ethical aspects of nuclear and mitochondrial DNA transfer.

Authors:  José Rafael Blesa; Julio Tudela; Justo Aznar
Journal:  Linacre Q       Date:  2016-05

10.  Mitochondrial Replacement Techniques, the Non-Identity Problem, and Genetic Parenthood.

Authors:  William Simkulet
Journal:  Asian Bioeth Rev       Date:  2021-05-08
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