Literature DB >> 23606117

Synthesis, structure and anti-acetylcholinesterase activity of 12a-O-methyl territrem B.

P F Chuo1, C P Ho.   

Abstract

12a-0-methyl territrem B was synthesized from TRB by treatment with dimethyl sulfate in methanolic NaOH. The structure of 12a-0-methyl territrem B was elucidated by uv, ir nmr and mass spectra and it is 2.5 times more potent than TRB in inhibitory activity on electric eel acetylcholinesterase (E. C. 3.1.1.7.) (AChE).

Entities:  

Year:  1995        PMID： 23606117     DOI： 10.1007/BF03192071

Source DB:  PubMed          Journal:  Mycotoxin Res        ISSN： 0178-7888            Impact factor:   3.833


  8 in total

1.  A new and rapid colorimetric determination of acetylcholinesterase activity.

Authors:  G L ELLMAN; K D COURTNEY; V ANDRES; R M FEATHER-STONE
Journal:  Biochem Pharmacol       Date:  1961-07       Impact factor: 5.858

2.  Acetylcholinesterase inhibition by territrem B derivatives.

Authors:  F C Peng
Journal:  J Nat Prod       Date:  1995-06       Impact factor: 4.050

3.  Biotransformation of territrems by S9 fraction from rat liver.

Authors:  K H Ling; C M Chiou; Y L Tseng
Journal:  Drug Metab Dispos       Date:  1991 May-Jun       Impact factor: 3.922

4.  The turnover numbers of acetylcholinesterase forms.

Authors:  M A Gordon; D E Carpenter; I B Wilson
Journal:  Mol Pharmacol       Date:  1978-03       Impact factor: 4.436

5.  NMR assignments of territrems A, B, and C and the structure of MB2, the major metabolite of territrem B by rat liver microsomal fraction.

Authors:  S S Lee; F C Peng; C M Chiou; K H Ling
Journal:  J Nat Prod       Date:  1992-02       Impact factor: 4.050

6.  Territrems, tremorgenic mycotoxins of Aspergillus terreus.

Authors:  K H Ling; C K Yang; F T Peng
Journal:  Appl Environ Microbiol       Date:  1979-03       Impact factor: 4.792

7.  Cleavage of territrems by alkaline hydrogen peroxide: Isolation and characterization of the aromatic moiety of territrems.

Authors:  K H Ling; B J Chen; Y W Peng; S C Tsai; F C Peng; C K Yang
Journal:  Mycotoxin Res       Date:  1987-09       Impact factor: 3.833

8.  Isolation, chemical structure, acute toxicity, and some physicochemical properties of territrem C from Aspergillus terreus.

Authors:  K H Ling; H H Liou; C M Yang; C K Yang
Journal:  Appl Environ Microbiol       Date:  1984-01       Impact factor: 4.792
  8 in total
  1 in total

1.  A computational view on the significance of E-ring in binding of (+)-arisugacin A to acetylcholinesterase.

Authors:  Ziyad F Al-Rashid; Richard P Hsung
Journal:  Bioorg Med Chem Lett       Date:  2015-06-27       Impact factor: 2.823
  1 in total

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