Literature DB >> 23605965

Effects of mycotoxins on the mixed lymphocyte reaction.

T Itoh1, K Ishii, Y Ueno.   

Abstract

Effects of toxic fungal metabolites on mixed lymphocyte reaction (MLR) using mouse splenocytes and on growth of mouse myeloma cells were examined. Among 25 toxins assayed, the IC50 values of emodin, luteoskyrin, sterlgmatocystin, deoxynivalenoi, 4-acetylnivalenol, T-2 toxin and fusaric acid for the MLR were lower than those for the cytotoxicity toward the myeloma cells, suggesting that these toxins possess suppressive activity to the cellular immune system.

Entities:  

Year:  1994        PMID： 23605965     DOI： 10.1007/BF03192253

Source DB:  PubMed          Journal:  Mycotoxin Res        ISSN： 0178-7888            Impact factor:   3.833


  25 in total

1.  Carcinogenicity of sterigmatocystin.

Authors:  I F Purchase; J J Van Der Watt
Journal:  Food Cosmet Toxicol       Date:  1970-06

2.  Toxicological approach to (+) rugulosin, an anthraquinoid mycotoxin of Penicillium rugulosum Thom.

Authors:  Y Ueno; I Ueno; N Sato; Y Iitoi; M Saito
Journal:  Jpn J Exp Med       Date:  1971-06

3.  A modified method of mixed lymphocyte reaction: establishment of the assay system and its application to extracts of fungal cultures.

Authors:  T Itoh; K Ishii; T Irikura; Y Ueno; A Kojima; Y Horie
Journal:  J Antibiot (Tokyo)       Date:  1993-10       Impact factor: 2.649

4.  Cytotoxic and immunotoxic effects of Fusarium mycotoxins using a rapid colorimetric bioassay.

Authors:  A Visconti; F Minervini; G Lucivero; V Gambatesa
Journal:  Mycopathologia       Date:  1991-03       Impact factor: 2.574

5.  Effect of aflatoxin B1 and major metabolites on phytohemeagglutinin-stimulated lymphoblastogenesis of bovine lymphocytes.

Authors:  A B Bodine; S F Fisher; S Gangjee
Journal:  J Dairy Sci       Date:  1984-01       Impact factor: 4.034

6.  Rapid colorimetric bioassay for screening of Fusarium mycotoxins.

Authors:  B A Rotter; B K Thompson; S Clarkin; T C Owen
Journal:  Nat Toxins       Date:  1993

7.  Cytotoxic effect of T-2 mycotoxin on cells in culture as determined by a rapid colorimetric bioassay.

Authors:  P S Holt; S Buckley; J O Norman; J R DeLoach
Journal:  Toxicon       Date:  1988       Impact factor: 3.033

8.  Production of 3-acetyldeoxynivalenol in shake culture.

Authors:  K Ishii; H Sato; Y Ueno
Journal:  Mycotoxin Res       Date:  1985-03       Impact factor: 3.833

9.  Cytotoxicity Evaluation of Mycotoxins by an MTT-Bioassay.

Authors:  G H Reubel; M Gareis; W M Amselgruber
Journal:  Mycotoxin Res       Date:  1987-09       Impact factor: 3.833

10.  Effect of T2 toxin on the spontaneous antibody-secreting cells and other non-lymphoid cells in the murine spleen.

Authors:  R Cooray; K Lindahl-Kiessling
Journal:  Food Chem Toxicol       Date:  1987-01       Impact factor: 6.023
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