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Literature DB >> 23605752

Molecular mechanisms of deoxynivalenol resistance in the yeastSaccharomyces cerevisiae.

G Adam¹, R Mitterbauer, A Raditschnig, B Poppenberger, T Karl, S Goritschnig, H Weindorfer, J Glössl.

Abstract

The production of trichothecene toxins is a suspected virulence mechanism of several plant pathogenic fungi. This hypothesis has been confirmed forGibberella zeae (Fusarium graminearum) by gene disruption experiments, suggesting in turn, that resistance against the fungal toxin is a relevant component ofFusarium resistance of the host plant. Our goal is therefore to identify molecular mechanisms of trichothecene resistance. Using yeast as a model system we have found the following resistance mechanisms and genes: a) reduced uptake of deoxynivalenol (PDR5), b) toxin modification and reduction of toxicity (AYT1), and c) formation of a resistant toxin target (RPL3). Homologous plant genes exist and are attractive candidates forFusarium resistance genes.

Entities: Chemical Disease Gene Species

Year: 2001 PMID： 23605752 DOI： 10.1007/BF03036704

Source DB: PubMed Journal: Mycotoxin Res ISSN： 0178-7888 Impact factor: 3.833

11 in total

1. A new efficient gene disruption cassette for repeated use in budding yeast.

Authors: U Güldener; S Heck; T Fielder; J Beinhauer; J H Hegemann
Journal: Nucleic Acids Res Date: 1996-07-01 Impact factor: 16.971

2. Complete inventory of the yeast ABC proteins.

Authors: A Decottignies; A Goffeau
Journal: Nat Genet Date: 1997-02 Impact factor: 38.330

Review 3. Non-macrocyclic trichothecenes.

Authors: J F Grove
Journal: Nat Prod Rep Date: 1988-04 Impact factor: 13.423

4. Trichothecene 3-O-acetyltransferase protects both the producing organism and transformed yeast from related mycotoxins. Cloning and characterization of Tri101.

Authors: M Kimura; I Kaneko; M Komiyama; A Takatsuki; H Koshino; K Yoneyama; I Yamaguchi
Journal: J Biol Chem Date: 1998-01-16 Impact factor: 5.157

5. Reduced virulence of Gibberella zeae caused by disruption of a trichothecene toxin biosynthetic gene.

Authors: R H Proctor; T M Hohn; S P McCormick
Journal: Mol Plant Microbe Interact Date: 1995 Jul-Aug Impact factor: 4.171

6. Toxic effects of deoxynivalenol on ribosomes and tissues of the spring wheat cultivars Frontana and Casavant.

Authors: J D Miller; M A Ewen
Journal: Nat Toxins Date: 1997

7. Production of mycotoxins by Fusarium species isolated in Germany. 2. Time course of deoxynivalenol and 3-acetyldeoxynivalenol formation by Fusarium graminearum in different liquid media.

Authors: M Schuster; J Lepschy; A Biber; G Engelhardt; P R Wallnöfer
Journal: Z Lebensm Unters Forsch Date: 1987-12

8. Cloning of yeast gene for trichodermin resistance and ribosomal protein L3.

Authors: H M Fried; J R Warner
Journal: Proc Natl Acad Sci U S A Date: 1981-01 Impact factor: 11.205

Review 9. Yeast multidrug resistance: the PDR network.

Authors: E Balzi; A Goffeau
Journal: J Bioenerg Biomembr Date: 1995-02 Impact factor: 2.945

10. A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae.

Authors: R S Sikorski; P Hieter
Journal: Genetics Date: 1989-05 Impact factor: 4.562

4 in total

1. A sensitive and inexpensive yeast bioassay for the mycotoxin zearalenone and other compounds with estrogenic activity.

Authors: Rudolf Mitterbauer; Hanna Weindorfer; Naser Safaie; Rudolf Krska; Marc Lemmens; Peter Ruckenbauer; Karl Kuchler; Gerhard Adam
Journal: Appl Environ Microbiol Date: 2003-02 Impact factor: 4.792