Histopathological and cytolosical abnormalities induced by fusarial toxins in mice (Mus musculus).

Three fusarial toxins vi z., zearal enone (ZEA), deoxynivalenol (DON) and T-2 were administered orally to mice (Mus musculus) under two different treatments. In the -first treatment, the toxins were -fed at the rate o-f 0.5 mg/kg body weight (ZEA), 3mg/kg body weight (DON), and 0.5mg/kg body weight (T-2) -for eight weeks (twice a week) . In another set o-f experiments the toxins were .given daily by mixing with the -feed at a concentration commonly -found in -food and -feed items as natural contaminants. The a-f-fected animals showed significant changes in body weight. T-2 toxins caused swelling o-f stomach in most o-f the treated animals. Portal and periportal fibrosis in liver was also very common. Enlargement o-f urinary bladder was observed in ZEA fed animals. Cytological studies in bonemarrow cells showed fragmentation, chromosome breaks, stickiness and clumping of chromosome.