Identification of chlamydosporol, a mycotoxin isolated from a culture of fusarium tricinctum.

Fusarium tricinctum strain (KF 260) isolated from wheat in Poland, produced on maize cultures a compound (C11H14O5, MW226) toxic toArtemia salina. The compound, identified by various spectroscopical tecniques as 5-hydroxy-4-methoxy-6,8a-dimethyl-6, 7-dihydro-2H, 8aH-pyrano/2, 3-b/pyran-2-one, was identical to chlamydosporol, a mycotoxin recentlydiscovered in cultures ofF._ chlamydosporum isolated from rice. The compound showed inhibitory effect on human lymphocyte proliferation at concentration of 25 μg/mL. LD50 onA. salina was 56 μg/mL.