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Literature DB >> 23605529

Ochratoxin A induced TNFα release from the isolated and blood- free perfused rat liver.

A Weidenbach¹, K Schuh, K Failing, E Petzinger.

Abstract

Ochratoxin A (OTA) a naturally occuring mycotoxin is nephrotoxic, hepatotoxic, teratogenic, embryotoxic, genotoxic, cancerogenic and immunosuppressive. Focussing on the immunemodulating effects, we found that OTA induces cytokine release from the isolated and bloodfree perfused rat liver. In the present study, we have characterized the liberation of tumor necrosis factor alpha (TNFα) by OTA and we described interactions with various mycotoxins andE.coli lipopolysaccharide (LPS).

Entities: Chemical Disease Gene Species

Year: 2000 PMID： 23605529 DOI： 10.1007/BF02940035

Source DB: PubMed Journal: Mycotoxin Res ISSN： 0178-7888 Impact factor: 3.833

13 in total

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Authors: A N Shakhov; M A Collart; P Vassalli; S A Nedospasov; C V Jongeneel
Journal: J Exp Med Date: 1990-01-01 Impact factor: 14.307

4 in total