Literature DB >> 23605519

Apoptosis in cultured renal epithelial cells caused by ochratoxin A.

G Schwerdt1, R Freudinger, C Schuster, S Silbernagl, M Gekle.   

Abstract

Apoptosis induction in renal epithelial cells caused by exposure to ochratoxin A (OTA) was studied. Nanomolar concentrations of OTA led to activation of caspase 3 with subsequent chromatin condensation and DNA ladder formation, both characteristic for cells undergoing apoptosis. Inhibition of the mitochondrial ATP/ADP carrier prevented OTA induced caspase activation showing that intact mitochondria are necessary for OTA induced apoptosis.

Entities:  

Year:  2000        PMID： 23605519     DOI： 10.1007/BF02940025

Source DB:  PubMed          Journal:  Mycotoxin Res        ISSN： 0178-7888            Impact factor:   3.833


  8 in total

1.  Nephritogenic ochratoxin A interferes with mitochondrial function and pH homeostasis in immortalized human kidney epithelial cells.

Authors:  S Eder; A Benesic; R Freudinger; J Engert; G Schwerdt; K Drumm; M Gekle
Journal:  Pflugers Arch       Date:  2000-08       Impact factor: 3.657

Review 2.  Mitochondrial control of apoptosis.

Authors:  G Kroemer; N Zamzami; S A Susin
Journal:  Immunol Today       Date:  1997-01

3.  Ochratoxin A, an inhibitor of mitochondrial transport systems.

Authors:  H Meisner; S Chan
Journal:  Biochemistry       Date:  1974-07-02       Impact factor: 3.162

4.  Ochratoxin A: inhibition of mitochondrial respiration.

Authors:  J H Moore; B Truelove
Journal:  Science       Date:  1970-05-29       Impact factor: 47.728

5.  Characterization of two MDCK-cell subtypes as a model system to study principal cell and intercalated cell properties.

Authors:  M Gekle; S Wünsch; H Oberleithner; S Silbernagl
Journal:  Pflugers Arch       Date:  1994-09       Impact factor: 3.657

6.  Ochratoxin A-induced stimulation of extracellular signal-regulated kinases 1/2 is associated with Madin-Darby canine kidney-C7 cell dedifferentiation.

Authors:  H Schramek; D Wilflingseder; V Pollack; R Freudinger; S Mildenberger; M Gekle
Journal:  J Pharmacol Exp Ther       Date:  1997-12       Impact factor: 4.030

7.  Immortalization of normal human kidney epithelial cells by nickel(II).

Authors:  G Tveito; I L Hansteen; H Dalen; A Haugen
Journal:  Cancer Res       Date:  1989-04-01       Impact factor: 12.701

8.  Exposure to ochratoxin A impairs organic anion transport in proximal-tubule-derived opossum kidney cells.

Authors:  C Sauvant; S Silbernagl; M Gekle
Journal:  J Pharmacol Exp Ther       Date:  1998-10       Impact factor: 4.030
  8 in total

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